4.3 Analysis of biomarkers following an aerobic exercise intervention for individuals recovering from concussion

Le résumé fourni par la source

Objective To compare neurotrophic, inflammatory, and axonal injury blood biomarker concentrations between a structured aerobic exercise protocol (SAEP) and usual care exercise protocol (UCEP) groups post-intervention. Design This study was a subset of a longitudinal, non-blinded randomized-controlled trial. Setting Academic Sport Medicine Clinic, University of Toronto. Participants Thirty-nine participants were enrolled in the study of which 13 participants had peripheral blood drawn at 7- and 21-days post-injury (PI). Six were allocated to the SAEP and 7 to the UCEP. Inclusion criteria included a concussion diagnosis by a sports medicine physician within 7-days PI, between 13–25 years old and ability to speak/understand English. Exclusion criteria included prior concussion within two weeks of presenting with concussion, presence of co-morbid injuries and pre-existing health conditions. Interventions (or Assessment of Risk Factors) Participants allocated to the SAEP protocol underwent a stepwise exercise protocol consisting of 8 exercise sessions performed over 11 days progressing in duration and intensity based on participants’ age-predicted maximal heart rate. Outcome Measures Primary outcome measures included concentrations of brain-derived neurotrophic factor, inflammatory cytokines and chemokines, or axonal injury biomarkers. Main Results No significant between-group differences for any of the blood biomarkers examined at 21-days PI were observed. Furthermore, the change in blood biomarker concentrations from 7- to 21-days PI between and within groups did not significantly differ. Conclusions Findings of this study suggest that exercise initiated acutely following concussion does not appear to influence resting levels of peripheral neurotrophic, inflammatory, and axonal injury blood biomarkers. Trial Registration ClinicalTrials.gov, no. NCT02969824

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