Systematic literature review of treatments used for refractory or unexplained chronic cough in adults
Rattachement africain : us, de, gb, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Refractory or unexplained chronic cough (RCC or UCC) is difficult to manage and is usually treated by the off-label use of drugs approved for other indications. OBJECTIVE: The objectives of this systematic literature review (SLR) were to identify and characterize the current published body of evidence for the efficacy and safety of treatments for RCC or UCC. METHODS: The SLR was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The SLRs pre-defined population included patients ≥18 years of age who were diagnosed with chronic cough. The review was not restricted to any intervention type or study comparator, nor by timeframe. RESULTS: A total of 20 eligible publications from 19 unique trials were included. Seventeen of these trials were randomized controlled trials and most (14/17) were placebo-controlled. There was considerable variability between trials in the definition of RCC or UCC, participant exclusion and inclusion criteria, outcome measurement timepoints, and the safety and efficacy outcomes assessed. Several trials identified significant improvements in cough frequency, severity, or health-related quality of life measures while participants were on treatment, although these improvements did not persist in any of the studies that included a post-treatment follow-up timepoint. CONCLUSIONS: In the absence of an approved therapy, placebo remains the most common comparator in trials of potential RCC or UCC treatments. The between-study comparability of the published evidence is limited by heterogeneity of study design, study populations, and outcomes measures, as well as by concerns regarding study size and risk of bias.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Systematic literature review of treatments used for refractory or unexplained chronic cough in adults
- Date Crossref
- 01/01/2024
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Inc. Merck & Co. pays non établi dans la noticeEntreprise
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German Red Cross pays non établi dans la noticeÉtablissement de santé
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Krankenhaus vom Roten Kreuz pays non établi dans la noticeÉtablissement de santé
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King's College London Institute of Pharmaceutical Science pays non établi dans la noticeUniversité ou école supérieure
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University of Rome Tor Vergata Department of Experimental Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Parma Department of Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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Health Economics and Outcomes Research (United Kingdom) pays non établi dans la noticeEntreprise
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Red Cross Hospital pays non établi dans la noticeÉtablissement de santé
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PRECISIONheor pays non établi dans la noticeInstitution
Merck & Co. — Inc., German Red Cross et Krankenhaus vom Roten Kreuz, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.