Clay Nanoparticles Ameliorate the Reproductive Toxicity Induced By Silver Nanoparticles in Adult Male Rats

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Introduction: Silver nanoparticles (Ag-NPs) are among the most commonly used nanoparticles in different fields. Clay nanoparticles (clay-NPs) are known for their antioxidant effect. This study was designed to investigate the reprotoxic effects of 100mg/kg/d BW of Ag-NPs (50 nm) on the adult male rat and also the possible ameliorative effect of 40 mg/kg/d of clay-NPs (100 nm) against these harmful effects. Methods: For this study, thirty-two adult male rats were randomly divided into four equal groups: the control group, the AgNPs group, the clay-NPs group, and the clay-NPs/AgNPs group. Ag-NPs (100 mg/kg) and/or clay-NPs (40 mg/kg) were administered orally for 60 days. The results: revealed that exposure to Ag-NPs adversely affected sperm motility, morphology, viability, and concentration. Additionally, Ag-NPs also induced oxidative stress, results of a comet assay revealed DNA degeneration in the sperm of rats. Morphometrical and histopathological examinations showed various histological alterations in the testes of rats intoxicated with Ag-NPs. Furthermore, co-administration of clay-NPs ameliorated most of these toxic effects of Ag-NPs, possibly via their antioxidative capacity.

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