Psychological Barriers to the Use of Opioid Analgesics for Treating Pain in Patients With Advanced Recurrent Cancer: A Multicenter Cohort Study
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Le résumé fourni par la source
Background: We aimed to gain insight into psychological barriers toward initiation of strong opioid analgesic use in patients with advanced recurrent cancer. Methods: This study included 46 patients who were prescribed with opioid analgesics for advanced recurrent cancer. The primary outcome was psychological barriers assessed using the Japanese version of the Barriers Questionnaire-II (JBQ-II). The secondary outcomes were psychological changes and pain relief one week after the induction of strong opioid analgesics. Results: The mean age of participants was 63.6 years. Furthermore, 26.1% had an Eastern Cooperative Oncology Group (ECOG) performance status of ≥3. The mean JBQ-II total score was 1.97 (95% confidence interval: 1.75–2.19). At the initiation of opioid therapy, there was no difference in the total scores between the baseline and one week later. Nevertheless, there was a significant difference in the subscale “disease progression” score (mean 2.97 vs. 2.59, difference in means 0.38, standard error 0.16, p = 0.026). Personalized Pain Goal (PPG) was achieved in about half of the participants, and a trend toward a higher score in the subscale “harmful effects” (concern about adverse events) was observed in those who did not achieve PPG. Conclusion: This study showed that patients with advanced recurrent cancer have psychological barriers to opioid induction. The relationship between the presence of psychological barriers before and after induction of opioid analgesics and the speed of pain improvement was determined. The results may provide fundamental information for prospective intervention studies to develop individualized education programs for patients with psychological barriers to opioids. Clinical Trial Registration Number UMIN000042443.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Psychological Barriers to the Use of Opioid Analgesics for Treating Pain in Patients With Advanced Recurrent Cancer: A Multicenter Cohort Study
- Date Crossref
- 19/01/2024
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tokyo University of Pharmacy and Life Sciences Department of Analytical Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Yokohama City University Medical Center Department of Pharmacy pays non établi dans la noticeÉtablissement de santé
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Yokohama City University pays non établi dans la noticeUniversité ou école supérieure
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National Cancer Center Hospital East Department of Pharmacy pays non établi dans la noticeÉtablissement de santé
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Tokyo Medical University Hospital Department of Pharmacy pays non établi dans la noticeÉtablissement de santé
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Yokohama Minami Kyosai Hospital pays non établi dans la noticeÉtablissement de santé
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Kameda Medical Center Department of Pharmacy pays non établi dans la noticeÉtablissement de santé
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Tohoku University Division of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Department of Pharmacy and Yokohama Minami Kyousai Hospital Department of Palliative and Supportive Care pays non établi dans la noticeÉtablissement de santé
Department of Analytical Chemistry — Tokyo University of Pharmacy and Life Sciences, Department of Pharmacy — Yokohama City University Medical Center et Yokohama City University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.