Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents

Résumé fourni par la source

Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.

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