Cost-Effectiveness Analysis of Digital Breast Tomosynthesis Added to Synthetic Mammography in Breast Cancer Screening in Brazil
Rattachement africain : br, gb, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Literature meta-analysis results show that digital breast tomosynthesis (DBT) combined with synthesized two-dimensional (s2D) mammograms can reduce recalls and improve breast cancer detection. Uncertainty regarding the screening of patients with breast cancer presents a health economic challenge, both in terms of healthcare resource use and quality of life impact on patients. OBJECTIVE: This study aims to estimate the cost effectiveness of DBT + s2D versus digital mammography (DM) used in a biennial breast cancer screening setting of women aged 40-69 years with scattered areas of fibroglandular breast density and heterogeneous dense breasts in the Brazilian supplementary health system. METHODS: A cost-effectiveness analysis was performed on the basis of clinical data obtained from a systematic review with meta-analysis performed to evaluate the analytical validity and clinical utility of DBT + s2D compared with DM. The search was conducted in the PubMed, Cochrane Library and Embase databases, with the main descriptors of the technology, a comparator, and the clinical condition in question, on 9 June 2022. The hybrid economic model (decision tree plus Markov model) simulated costs and outcomes over a lifetime for women aged 40-69 years with scattered areas of fibroglandular breast density and heterogeneous dense breasts. We analyzed incremental cost-effectiveness ratio (ICER) to measure the incremental cost difference per quality-adjusted life year (QALY) of adding DBT + s2D to breast cancer screening. RESULTS: DBT + s2D incurred a cost saving of € 954.02 per patient, in the time horizon of 30 years, compared with DM, and gained 5.1989 QALYs, which would be considered a dominant intervention. These results were confirmed in sensitivity analyses. CONCLUSION: Switching from DM to biennial DBT + s2D was cost effective. Furthermore, reductions in false-positive recall rates should also be considered in decision making.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cost-Effectiveness Analysis of Digital Breast Tomosynthesis Added to Synthetic Mammography in Breast Cancer Screening in Brazil
- Date Crossref
- 18/01/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Brazilian Academy of Sciences pays non établi dans la noticeOrganisation à but non lucratif
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Fundação João Pinheiro pays non établi dans la noticeOrganisme public
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Universidade Federal de Minas Gerais pays non établi dans la noticeUniversité ou école supérieure
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Universidade Estadual de Montes Claros pays non établi dans la noticeUniversité ou école supérieure
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Universidade Estadual Paulista (Unesp) pays non établi dans la noticeUniversité ou école supérieure
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Seacroft Hospital Breast Screening Unit pays non établi dans la noticeÉtablissement de santé
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center Department of Medical Imaging pays non établi dans la noticeOrganisme public
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The Netherlands Cancer Institute Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Oncode Institute pays non établi dans la noticeUniversité ou école supérieure
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Queen's University Belfast Patrick G Johnston Centre for Cancer Research pays non établi dans la noticeUniversité ou école supérieure
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University of East Anglia Norwich Medical School pays non établi dans la noticeUniversité ou école supérieure
Brazilian Academy of Sciences, Fundação João Pinheiro et Universidade Federal de Minas Gerais, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.