Anemia, iron, and HIV: decoding the interconnected pathways: A review
Rattachement africain : Ouganda, Nigéria, Rwanda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
This review delves into the intricate relationship between anemia, iron metabolism, and human immunodeficiency virus (HIV), aiming to unravel the interconnected pathways that contribute to the complex interplay between these 3 entities. A systematic exploration of relevant literature was conducted, encompassing studies examining the association between anemia, iron status, and HIV infection. Both clinical and preclinical investigations were analyzed to elucidate the underlying mechanisms linking these components. Chronic inflammation, a hallmark of HIV infection, disrupts iron homeostasis, impacting erythropoiesis and contributing to anemia. Direct viral effects on bone marrow function further compound red blood cell deficiencies. Antiretroviral therapy, while essential for managing HIV, introduces potential complications, including medication-induced anemia. Dysregulation of iron levels in different tissues adds complexity to the intricate network of interactions. Effective management of anemia in HIV necessitates a multifaceted approach. Optimization of antiretroviral therapy, treatment of opportunistic infections, and targeted nutritional interventions, including iron supplementation, are integral components. However, challenges persist in understanding the specific molecular mechanisms governing these interconnected pathways. Decoding the interconnected pathways of anemia, iron metabolism, and HIV is imperative for enhancing the holistic care of individuals with HIV/AIDS. A nuanced understanding of these relationships will inform the development of more precise interventions, optimizing the management of anemia in this population. Future research endeavors should focus on elucidating the intricate molecular mechanisms, paving the way for innovative therapeutic strategies in the context of HIV-associated anemia.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Anemia, iron, and HIV: decoding the interconnected pathways: A review
- Date Crossref
- 12/01/2024
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kampala International University Department of Medical Laboratory Science Kampala International University, Ouganda (code pays fourni par la source)Université ou école supérieure
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Nnamdi Azikiwe University Department of Medical Laboratory Science Nnewi, Nigéria (code pays fourni par la source)Université ou école supérieure
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INES-Ruhengeri Rwanda (code pays fourni par la source)Université ou école supérieure
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School of Nursing Science Kampala International University, Ouganda (pays nommé en fin d’affiliation)Université ou école supérieure
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Faculty of Fundamental Applied Sciences Department of Biomedical Laboratory Sciences Musanze District, Rwanda (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Medical Laboratory Science — Kampala International University (Kampala International University, Ouganda), Department of Medical Laboratory Science — Nnamdi Azikiwe University (Nnewi, Nigéria) et INES-Ruhengeri (Rwanda), avec 2 autres affiliations. Pays d’affiliation : Ouganda, Nigéria, Rwanda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.