Efficacy of vagus nerve stimulation for children with drug-resistant epilepsy: Retrospective study

Le résumé fourni par la source

Introduction: According to current investigations, there are controversy in our knowledge regarding the safety and efficacy of Vagus Nerve Stimulation (VNS) in children younger than 12 years old. Therefore, we performed this study and aimed to better evaluate the safety and efficacy of VNS in children younger than 12 years. Method: The retrospective study comprised two groups. In the first group, patients (N= 19) underwent VNS implantation procedure and second group, (N=21) received no VNS implantation. The main study parameters are as follows: (1) Primary outcome evaluated the proportion of cases with >50% reduction of seizures at the last follow-up. (2) changes in patients’ status in VNS group after procedure compared to before procedure. (3) patient's complaints in VNS group compared to control group. Results: Our results demonstrated that there was a significant reduction in the frequency of seizures (per month) in patients 6 months after VNS surgery compared to before VNS surgery (1044.3 ± 1526.7 VS 220.7 ± 421.6; P value = 0.028). 57.9% of patients underwent VNS showed the response rate of 50% reduction in seizure frequency. There was significant improvement in memory problem, work/ school limitation, social limitation, and tachycardia 6 months after VNS procedure compared to before VNS procedure in patients. The most common reported side effects were difficulty swallowing (31.5%) and coughing (31.5%) followed by stomach discomfort (15.8%). Conclusion: Considering the significant reduction in the frequency of seizures and improvement of life aspects including in memory problem, work/ school limitation, social limitation, we recommend VNS as an effective treatment modality for drug-resistant epilepsy in children. However, the combination of VNS with other treatment modalities that could improve other aspects of quality such as energy levels, sleep pattern, and feeling management of life is recommended.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.