Induced Sputum Role in Severe Asthma Phenotyping

Le résumé fourni par la source

Induced sputum is a method which, by inhaling hypertonic saline, provoke a person to expectorate certain amount of bronchial secretion. Sputum sample obtained consists of liquid and celullar phase. It is used over the years to investigate airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD). Results of cell counts in induced sputum is essential in differentiation of airway eosinophilia or neutrophilia or both, or a determination of paucigranulocytic phenotype. Obtained severe asthma phenotype due to airway inflammation help us to select biological therapy and predict responders. The correlation between “noninvasive” measures such as blood eosinophilia, or fraction of exhaled nitric oxide (FeNO) with sputum eosinophils is suboptimal. Induced sputum is a good and reproducible discriminator for eosinophilic asthma. There asre some safety concerns as induced sputum procedure can provoke adverse effects such as bronchoconstriction and dyspnea, which is reversible to standardized therapy. Sputum induction is safe and well tolerated by patients with severe asthma, which supports its use in clinical and research practice.

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