Cluster Analysis to Identify Clinical Subtypes of Ménière's Disease
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Le résumé fourni par la source
OBJECTIVE: To identify distinct clinical subtypes of Ménière's disease by analyzing data acquired from a UK registry of patients who have been diagnosed with Ménière's disease. STUDY DESIGN: Observational study. METHODS: Patients with Ménière's disease were identified at secondary/tertiary care clinics. Cluster analysis was performed by grouping participants sharing similar characteristics and risk factors into groups based on a defined measure of similarity. RESULTS: A total of 411 participants were recruited into this study. Two main clusters were identified: participants diagnosed with ear infections (OR = 0.30, p < 0.014, 95% CI: 0.11-0.78) were more likely to be allocated in Cluster 1 (C1). Participants reporting tinnitus in both ears (OR = 11.89, p < 0.001, 95% CI: 4.08-34.64), low pitched tinnitus (OR = 21.09, p < 0.001, 95% CI: 7.47-59.54), and those reporting stress as a trigger for vertigo attacks (OR = 14.94, p < 0.001, 95% CI: 4.54-49.10) were significantly more likely to be in Cluster 2 (C2). Also, participants diagnosed with Benign Paroxysmal Positional Vertigo (OR = 13.14, <0.001, 95% CI: 4.35-39.74), autoimmune disease (OR = 5.97, p < 0.007, 95% CI: 1.62-22.03), depression (OR = 4.72, p < 0.056, 95% CI: 0.96-23.24), migraines (OR = 3.13, p < 0.008, 95% CI: 1.34-7.26), drug allergy (OR = 3.25, p < 0.029, 95% CI: 1.13-9.34), and hay fever (OR = 3.12, p < 0.009, 95% CI: 1.33-7.34) were significantly more likely to be clustered in C2. CONCLUSIONS: This study supports the hypothesis that Ménière's disease is a heterogeneous condition with subgroups that may be identifiable by clinical features. Two main clusters were identified with differing putative etiological factors. LEVEL OF EVIDENCE: 3 Laryngoscope, 134:3286-3292, 2024.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cluster Analysis to Identify Clinical Subtypes of Ménière's Disease
- Date Crossref
- 06/01/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Norfolk and Norwich University Hospitals NHS Foundation Trust Department of Otolaryngology pays non établi dans la noticeÉtablissement de santé
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Guy's and St Thomas' NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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University of East Anglia Norwich Medical School pays non établi dans la noticeUniversité ou école supérieure
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University Hospitals of Leicester NHS Trust Department of Otolaryngology pays non établi dans la noticeÉtablissement de santé
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Imperial College Healthcare NHS Trust Department of Otolaryngology pays non établi dans la noticeÉtablissement de santé
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Department of Otolaryngology Guy's and St. Thomas' NHS Foundation Trust London UK pays non établi dans la noticeOrganisation à but non lucratif
Department of Otolaryngology — Norfolk and Norwich University Hospitals NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust et Norwich Medical School — University of East Anglia, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.