Association of gestational cardiovascular health with infant neurodevelopment: A prospective study in Hefei of Anhui, China
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Le résumé fourni par la source
We investigate the prospective the association of gestational cardiovascular health (CVH) with infant neurodevelopment, and whether such relation was mediated by cord blood metabolites. The data come from the prospective birth cohort study in Hefei of Anhui, China. A total of 1714 mother-infant pairs are included from March 2018 and June 2021. CVH was evaluated at 24 to 28 gestational weeks by the combination of five metrics: body mass index, blood pressure, total cholesterol, glucose, and smoking. Cord blood samples were collected at delivery for the detection of related indicators. Infant neurodevelopment at 12 months was assessed by the Ages and Stages Questionnaire Edition 3 (ASQ-3). We stratified the status of CVH into three levels, ideal, intermediate, and poor. Compared with the ideal CVH, poor CVH was associated with infant communication domain failure (RR = 2.06; 95 %CI, 1.24-3.42) and cord blood C-peptide levels (β = 0.09; 95 %CI, 0.06-0.13) were higher. Cord blood C-peptide level with infant communication domain failure risk increased (RR = 3.43, 95 %CI: 2.11-5.58). Mediation analysis showed that cord blood C-peptide mediated 13.9 % of the effect. Key findings indicated that maternal poor CVH at 24 to 28 weeks gestation was associated with an increased risk of infant neurodevelopment at ASQ-3 failure in the communication domain, and cord blood C-peptide might mediate this association. The findings, if confirmed by replications, specific nursing cares among pregnant women with poor CVH, might have implications for the offspring neurodevelopment prevention strategies targeting.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association of gestational cardiovascular health with infant neurodevelopment: A prospective study in Hefei of Anhui, China
- Date Crossref
- 01/02/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Anhui Medical University Anhui Provincial Key Laboratory of Population Health and Aristogenics pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Anhui Medical University pays non établi dans la noticeÉtablissement de santé
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School of Public Health Department of Maternal pays non établi dans la noticeUniversité ou école supérieure
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MOE Key Laboratory of Population Health Across Life Cycle pays non établi dans la noticeStructure de recherche
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School of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
Anhui Provincial Key Laboratory of Population Health and Aristogenics — Anhui Medical University, First Affiliated Hospital of Anhui Medical University et Department of Maternal — School of Public Health, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.