Active close contact investigation of tuberculosis through computer-aided detection and stool Xpert MTB/RIF among people living in Oromia Region, Ethiopia (CADOOL Study): protocol for a prospective, cross-sectional study
Rattachement africain : it, Éthiopie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: Pulmonary tuberculosis (TB) is an infectious disease with high incidence in low-income countries (LICs); it remains one of the infectious diseases with the highest mortality in the world, especially in LICs. It is crucial to recognise and diagnose TB as soon as possible, but microbiological tests on sputum are not always sensitive enough. New methods for an early diagnosis of TB are needed. In this study, we will investigate the role of two different tests to detect TB in Ethiopia (where the prevalence of TB is high): molecular search for TB in stool samples with Xpert assay and detection of pulmonary TB signs on chest X-rays with CAD4TB technology. METHODS AND ANALYSIS: and household contacts of at least 4 years of age will be enrolled, with a target sample size of 231 patients. Trained staff will label household contacts as 'possible TB' cases or not according to their symptoms; when TB is possible, a stool Xpert and computer-aided detection on chest X-ray will be performed, alongside standard diagnostic methods, assessing the diagnostic accuracy of CAD4TB compared with Xpert MTB/RIF during TB contact investigation and the accuracy of stool Xpert compared with sputum Xpert. ETHICS AND DISSEMINATION: This study has been approved by the Oromia Health Bureau Research Ethics Committee (ref no BFO/MBTFH/1-16/100023). All information obtained will be kept confidential. Selected investigators will have access to data, while international partners will sign a dedicated data protection agreement. Eligible participants will receive brief information about the study before being asked to participate and they will provide written informed consent. Results will be disseminated through peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT05818059.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Active close contact investigation of tuberculosis through computer-aided detection and stool Xpert MTB/RIF among people living in Oromia Region, Ethiopia (CADOOL Study): protocol for a prospective, cross-sectional study
- Date Crossref
- 01/12/2023
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Bari Aldo Moro Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) pays non établi dans la noticeUniversité ou école supérieure
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Oromiyaa Regional Health Bureau Éthiopie (code pays fourni par la source)Organisme public
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Doctors with Africa Cuamm Addis Ababa Coordination Office, Éthiopie (pays nommé en fin d’affiliation)Organisation à but non lucratif
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Armauer Hansen Research Institute Mycobacterial Diseases Research Addis Ababa, Éthiopie (code pays fourni par la source)Structure de recherche
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Istituto Nazionale di Statistica pays non établi dans la noticeStructure de recherche
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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St Luke Catholic Hospital Éthiopie (pays nommé en fin d’affiliation)Établissement de santé
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Health Research Team Addis Ababa, Éthiopie (pays nommé en fin d’affiliation)Institution
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Independent statistician pays non établi dans la noticeInstitution
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University of Padova Biostatistics pays non établi dans la noticeUniversité ou école supérieure
Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) — University of Bari Aldo Moro, Oromiyaa Regional Health Bureau (Éthiopie) et Doctors with Africa Cuamm (Addis Ababa Coordination Office, Éthiopie), avec 7 autres affiliations. Pays d’affiliation : Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.