Altered functional connectivity after pilocarpine-induced seizures revealed by intrinsic optical signals imaging in awake mice
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Le résumé fourni par la source
Significance: Comorbidities such as mood and cognitive disorders are often found in individuals with epilepsy after seizures. Cortex processes sensory, motor, and cognitive information. Brain circuit changes can be studied by observing functional network changes in epileptic mice's cortex. Aim: . Approach: Intrinsic optical signal and EEG were used to monitor cortical activity in awake mice within 4 h after pilocarpine induction. It was divided into three periods according to the behavior and EEG of the mice: baseline, onset of seizures (onset, including seizures and resting in between seizure events), and after seizures (post, without seizures). Changes in cortical activity were compared between the baseline and after seizures. Results: Hemoglobin levels increased significantly, particularly in the parietal association cortex (PT), retrosplenial cortex (RS), primary visual cortex (V1), and secondary visual cortex (V2). The network-wide functional connectivity changed post seizures, e.g., hypoconnectivity between PT and visual-associated cortex (e.g., V1 and V2). In contrast, connectivity between the motor-associated cortex and most other regions increased. In addition, the default mode network (DMN) also changed after seizures, with decreased connectivity between primary somatosensory region (SSp) and visual region (VIS), but increased connectivity involving anterior cingulate cortex (AC) and RS. Conclusions: Our results provide references for understanding the mechanisms behind changes in brain circuits, which may explain the profound effects of seizures on comorbid health conditions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Altered functional connectivity after pilocarpine-induced seizures revealed by intrinsic optical signals imaging in awake mice
- Date Crossref
- 19/12/2023
- Éditeur
- SPIE-Intl Soc Optical Eng
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Children's Hospital of Zhejiang University pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital Zhejiang University pays non établi dans la noticeÉtablissement de santé
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Wuhan National Laboratory for Optoelectronics pays non établi dans la noticeStructure de recherche
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Huazhong University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Hangzhou City University pays non établi dans la noticeUniversité ou école supérieure
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Zhejiang University School of Medicine Children’s Hospital pays non établi dans la noticeUniversité ou école supérieure
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These authors contributed equally pays non établi dans la noticeInstitution
Children's Hospital of Zhejiang University, First Affiliated Hospital Zhejiang University et Wuhan National Laboratory for Optoelectronics, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.