New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
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Patricia Liana Cristodor,1,2,* Alexandru Nechifor,3,* Silvia Fotea,3,* Thomas Nadasdy,2,4 Yousef Bahloul,2,5 Alin Codrut Nicolescu,6,* Alin Laurentiu Tatu3,4,7,8 1Center for the Morphologic Study of the Skin MORPHODERM, University of Medicine and Pharmacy “Victor Babeș”, Timișoara, TM, Romania; 2Dermatology Department, Spitalul Clinic Municipal de Urgenta Timisoara, Timişoara, TM, Romania; 3Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, GL, Romania; 4Multidisciplinary Integrative Center for Dermatologic Interface Research MIC-DIR, Galati, GL, Romania; 5PhD Studies Department, University of Medicine and Pharmacy, Victor Babeș” Timișoara, Timișoara, TM, Romania; 6Department of Dermatology, ‘Roma’ Medical Center for Diagnosis and Treatment, Bucharest, Romania; 7Dermatology Department, “Sf. Cuvioasa Parascheva” Clinical Hospital of Infectious Diseases, Galati, GL, Romania; 8Research Center in the Field of Medical and Pharmaceutical Sciences ReFORM-UDJ, Galati, GL, Romania*These authors contributed equally to this workCorrespondence: Thomas Nadasdy; Yousef Bahloul, Dermatology Department, Spitalul Clinic Municipal de Urgenta Timisoara, str. Ofcea nr.24, Timişoara, TM, 300558, Romania, Tel +40 751609000, Email thomas.nadasdy@gmail.com; dr.yousef.bahloul@gmail.comAbstract: There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a similar mechanism of action, we also hypothesize that a similar medication, nintedanib, might have similar applications. We also propose that a liposomal technology may assist in the penetration of nintedanib and enhance its clinical effects.Keywords: nintedanib, pirfenidone, keloid, scarring, fibroblast
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