Accès ouvert déclaré
2023
article
Vaccine Effectiveness Against Influenza A–Associated Hospitalization, Organ Failure, and Death: United States, 2022–2023
Nathaniel M. Lewis, Yuwei Zhu, Ithan D. Peltan, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Jay S. Steingrub, Nathan I. Shapiro, Abhijit Duggal, William S. Bender, Leyla Taghizadeh, Samuel M. Brown, David N. Hager, Michelle N. Gong, Amira Mohamed, Matthew C. Exline, Akram Khan, Jennifer G. Wilson, Nida Qadir, Steven Y. Chang, Adit A. Ginde, Nicholas M. Mohr, Christopher Mallow, Adam S. Lauring, Nicholas J. Johnson, Kevin W. Gibbs, Jennie H. Kwon, Cristie Columbus, Robert Gottlieb, Catherine Raver, Ivana A. Vaughn, Mayur Ramesh, Cassandra Johnson, Lois Lamerato, Basmah Safdar, Jonathan D. Casey, Todd W. Rice, Natasha Halasa, James D. Chappell, Carlos G. Grijalva, H. Keipp Talbot, Adrienne Baughman, Kelsey N. Womack, Sydney A. Swan, Elizabeth Harker, Ashley M. Price, Jennifer DeCuir, Diya Surie, Sascha Ellington, Wesley H. Self, Nicole Calhoun, Joselyn Cravens, Judy Herrick, Amanda McKillop, Eric Hoffman, Ashley Graves, Martha Zayed, Michael Smith, Baylor Scott, White Health, T. L. Fisher, Mariana Hurutado-Rodriguez, Taryn Kruse, Symone Dunkley, Gabriela Pérez, Ashley Bychkowski, Therissa Grefsrud, Lori-Ann Kozikowski, Lesley De Souza, Scott Ouellette, Michael Bolstad, Brianna Coviello, Robert A. Ciottone, Arnaldo deVilla, Ana Grafals, Conor Higgins, Carlo Ottanelli, Kimberly Redman, Douglas Scaffidi, Alexander Weingart, Meredith McMorrow, Jennifer DeCuir, Omar Mehkri, Megan Mitchell, Zachary Griffith, Connery Brennan, Kiran Ashok, Bryan Poynter, Laurence W. Busse, Caitlin ten Lohuis, Nicholas Stanley, Sophia Zhang, Matthew E. Prekker, Anne Frosch, Audrey Hendrickson, Stephen D. Douglas, Kowsar Hurreh, Cassie Smith, Hunter Marshall, Harith Ali, Minh Q. Phan, Rahul Nair, Jen-Ting Chen, Sarah Karow, Maryiam Khan, Madison So, Connor Snyder, Gabrielle Swoope, David W. Smith, Brooke Lee, Amanie Rasul, Manisha Pathak, Zachery Lewald, R. Eddie Wilson, José Peña, Genesis Briceño, Cassandra A Ahmed, Jesus Martinez, Edvinas Pocius, Minn Oh, Jessica Hyde, Sherie Gause, Jennifer G. Wilson, Alexandra June Gordon, Cynthia Pérez, Lily Lau, Ismail Bekiroglu, Cody Tran, Trevor Frankel, Omai B. Garner, Sukantha Chandrasekaran, David J. Douin, Amanda Martinez, David Huynh, Aimee Steinwand, Amy P. Sullivan, Cori Withers, Anne Zepeski, Paul Nassar, Shannon R. Landers, Karin Nielsen, Noble Briggs, Cathy Fairfield, A. Imogen Peebles, Chris Mallow, Carolina Rivas, Emily T. Martin, Arnold S. Monto, EJ McSpadden, Rachel Truscon, Anne Kaniclides, Lara Thomas, Ramsay Bielak, Weronika Damek Valvano, Rebecca Fong, William J. Fitzsimmons, Christopher Blair, Julie Gilbert, Leigh Papalambros, Ankur Holz, Vasisht Srinivasan, Christine D Crider, Kyle A Steinbock, Thomas C Paulsen, Layla A. Anderson, Ian Jones, Jillian P. Rhoads, Christy Kampe, Jakea Johnson, William B. Stubblefield, Laura Short, Lauren J Ezzell, Margaret E Whitsett, Rendie McHenry, Samarian J Hargrave, Marcia Blair, Jennifer L Luther, Claudia Guevara Pulido, Bryan P M Peterson, D. Clark Files, Leigha Landreth, Madeline Hicks, Lisa Parks, Bijal A. Parikh, David McDonald, Carleigh Samuels, Lucy Vogt, Caroline A. O’Neil, Alyssa Valencia, Tiffany Hink, Gabriela Cantu Perez, Kim Beney, Rachna Jayaprakash, Sindhuja Koneru, Jean Ashley Lava, Zina Pinderi, Melissa Resk, Anirudh Goyal, Lauren DeLamielleure, Michael Kosover, Carolyn Brokowski
37Citations signalées, ce qui n’est pas une note de qualité
35Institutions déclarées
1Pays d’affiliation déclarés
Rattachement africain : us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Influenza circulation during the 2022-2023 season in the United States largely returned to pre-coronavirus disease 2019 (COVID-19)-pandemic patterns and levels. Influenza A(H3N2) viruses were detected most frequently this season, predominately clade 3C.2a1b.2a, a close antigenic match to the vaccine strain. METHODS: To understand effectiveness of the 2022-2023 influenza vaccine against influenza-associated hospitalization, organ failure, and death, a multicenter sentinel surveillance network in the United States prospectively enrolled adults hospitalized with acute respiratory illness between 1 October 2022, and 28 February 2023. Using the test-negative design, vaccine effectiveness (VE) estimates against influenza-associated hospitalization, organ failures, and death were measured by comparing the odds of current-season influenza vaccination in influenza-positive case-patients and influenza-negative, SARS-CoV-2-negative control-patients. RESULTS: A total of 3707 patients, including 714 influenza cases (33% vaccinated) and 2993 influenza- and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative controls (49% vaccinated) were analyzed. VE against influenza-associated hospitalization was 37% (95% confidence interval [CI]: 27%-46%) and varied by age (18-64 years: 47% [30%-60%]; ≥65 years: 28% [10%-43%]), and virus (A[H3N2]: 29% [6%-46%], A[H1N1]: 47% [23%-64%]). VE against more severe influenza-associated outcomes included: 41% (29%-50%) against influenza with hypoxemia treated with supplemental oxygen; 65% (56%-72%) against influenza with respiratory, cardiovascular, or renal failure treated with organ support; and 66% (40%-81%) against influenza with respiratory failure treated with invasive mechanical ventilation. CONCLUSIONS: During an early 2022-2023 influenza season with a well-matched influenza vaccine, vaccination was associated with reduced risk of influenza-associated hospitalization and organ failure.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Vaccine Effectiveness Against Influenza A–Associated Hospitalization, Organ Failure, and Death: United States, 2022–2023
- Date Crossref
- 05/12/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Influenza Virus Research StudiesRespiratory viral infections researchSARS-CoV-2 and COVID-19 Research