Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial
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Le résumé fourni par la source
Background The optimal target for systemic oxygenation in critically ill children is unknown. Liberal oxygenation is widely practiced, but has been associated with harm in paediatric patients. We aimed to evaluate whether conservative oxygenation would reduce duration of organ support or incidence of death compared to standard care. Methods Oxy-PICU was a pragmatic, multicentre, open-label, randomised controlled trial in 15 UK paediatric intensive care units (PICUs). Children admitted as an emergency, who were older than 38 weeks corrected gestational age and younger than 16 years receiving invasive ventilation and supplemental oxygen were randomly allocated in a 1:1 ratio via a concealed, central, web-based randomisation system to conservative peripheral oxygen saturations ([SpO 2 ] 88–92%) or liberal (SpO 2 >94%) targets. The primary outcome was the duration of organ support at 30 days following random allocation, a rank-based endpoint with death either on or before day 30 as the worst outcome (a score equating to 31 days of organ support), with survivors assigned a score between 1 and 30 depending on the number of calendar days of organ support received. The primary effect estimate was the probabilistic index, a value greater than 0·5 indicating more than 50% probability that conservative oxygenation is superior to liberal oxygenation for a randomly selected patient. All participants in whom consent was available were included in the intention-to-treat analysis. The completed study was registered with the ISRCTN registry (ISRCTN92103439). Findings Between Sept 1, 2020, and May 15, 2022, 2040 children were randomly allocated to conservative or liberal oxygenation groups. Consent was available for 1872 (92%) of 2040 children. The conservative oxygenation group comprised 939 children (528 [57%] of 927 were female and 399 [43%] of 927 were male) and the liberal oxygenation group included 933 children (511 [56%] of 920 were female and 409 [45%] of 920 were male). Duration of organ support or death in the first 30 days was significantly lower in the conservative oxygenation group (probabilistic index 0·53, 95% CI 0·50–0·55; p=0·04 Wilcoxon rank-sum test, adjusted odds ratio 0·84 [95% CI 0·72–0·99]). Prespecified adverse events were reported in 24 (3%) of 939 patients in the conservative oxygenation group and 36 (4%) of 933 patients in the liberal oxygenation group. Interpretation Among invasively ventilated children who were admitted as an emergency to a PICU receiving supplemental oxygen, a conservative oxygenation target resulted in a small, but significant, greater probability of a better outcome in terms of duration of organ support at 30 days or death when compared with a liberal oxygenation target. Widespread adoption of a conservative oxygenation saturation target (SpO 2 88–92%) could help improve outcomes and reduce costs for the sickest children admitted to PICUs. Funding UK National Institute for Health and Care Research Health Technology Assessment Programme.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial
- Date Crossref
- 01/01/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Great Ormond Street Hospital Children's Acute Transport Service pays non établi dans la noticeÉtablissement de santé
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Great Ormond Street Hospital for Children NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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University College London Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Biomedical Research Centre pays non établi dans la noticeUniversité ou école supérieure
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Intensive Care National Audit & Research Centre pays non établi dans la noticeOrganisation à but non lucratif
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Newcastle upon Tyne Hospitals NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Great North Children's Hospital Department of Paediatric Intensive Care pays non établi dans la noticeÉtablissement de santé
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Newcastle University Department of Paediatric Intensive Care pays non établi dans la noticeUniversité ou école supérieure
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University of Leicester Department of Population Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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Evelina London Children's Healthcare pays non établi dans la noticeÉtablissement de santé
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University Hospital Southampton NHS Foundation Trust Paediatric Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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Imperial College London pays non établi dans la noticeUniversité ou école supérieure
Children's Acute Transport Service — Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust et Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Biomedical Research Centre — University College London, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.