Association between fat‐free mass and survival in critically ill patients with COVID‐19: A prospective cohort study
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Le résumé fourni par la source
BACKGROUND: Most critically ill patients with COVID-19 experience malnutrition and weight loss associated with negative clinical outcomes. Our primary aim was to assess body composition during acute and late phase of illness in these patients in relation to clinical outcome and secondary to tailored nutrition support. METHODS: This prospective cohort study included adult critically ill patients with COVID-19. Body composition (fat-free mass [FFM] [exposure of interest], fat mass [FM], skeletal muscle mass [SMM], and phase angle [PA]) was determined with multifrequency bioelectrical impedance analyses in the acute and late phase. Nutrition support data were collected simultaneously. Clinical outcome was defined as intensive care unit (ICU) survival (primary outcome) and 30-90 days thereafter, duration of mechanical ventilation, and length of ICU stay and length of hospital stay (LOS). Nonparametric tests and regression analyses were performed. RESULTS: ). Median weight change during ICU stay was -3 kg: +3 kg FM and -6 kg FFM (-4 kg SMM). Body composition changed significantly (P < 0.001). Regarding clinical outcome, only low PA was associated with prolonged LOS (odds ratio = 0.83, 95% CI = 0.72-0.96; P = 0.015). Patients with optimal protein intake (>80%) during acute phase maintained significantly more FFM (2.7 kg, P = 0.047) in the late phase compared with patients who received <80%. CONCLUSION: FFM decreased significantly during acute and late phase of illness, but we observed no association with ICU survival. Only low PA was associated with prolonged LOS. FFM wasting likely occurred because of disease severity and immobility.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association between fat‐free mass and survival in critically ill patients with COVID‐19: A prospective cohort study
- Date Crossref
- 27/12/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Erasmus MC pays non établi dans la noticeÉtablissement de santé
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Erasmus University Rotterdam pays non établi dans la noticeUniversité ou école supérieure
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Erasmus MC - Sophia Children’s Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Internal Medicine pays non établi dans la noticeInstitution
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Department of Intensive Care Medicine Erasmus Medical Centre Rotterdam the Netherlands pays non établi dans la noticeInstitution
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Department of Paediatrics and Paediatric Surgery Erasmus Medical Centre ‐ Sophia Children's Hospital Rotterdam the Netherlands Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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Erasmus Medical Centre - Sophia Children's Hospital Department of Paediatrics and Paediatric Surgery pays non établi dans la noticeÉtablissement de santé
Erasmus MC, Erasmus University Rotterdam et Erasmus MC - Sophia Children’s Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.