Editorial: Emerging talents in B cell biology: 2022

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This Research Topic on Emerging Talents in B cell Biology 2022 highlights the crucial role of young investigators in the field of B cell biology.These newcomers to the field often perform key research and write excellent dissertations or theses that are not distributed to a broader scientific community.Multiple factors might prevent the publication of student research.For example, the process of participating in a peer review process might appear daunting, and moving to a new position might hamper the publication of a project that was accomplished in another group.However, many outstanding pioneers in the field of B cell biology, including Nobel prize laureates Suzumi Tonegawa and Georges Kohler, have published pivotal manuscripts quite early in their careers.This Research Topic presents the work of outstanding young researchers in the field of B cell biology who began their publication activities within the last three years.These newcomers represent four different countries.Due to self-perceived equal contributions by more than one first author, eight first authors are reported among the four manuscripts.It is noteworthy that the first authors in four are women.Moreover, the majority of coauthors are also female, and four of the seven senior authors are male.This cohort facilitates current awareness of increasing female participation in academia and in the biomedical field in particular: although further interpretation is beyond our area of competence.The Research Topic includes one original article and three review articles and spans a large area of current hot topics in B cell biology:Zheremyan et al. present original research aiming to explore stimuli that have the potential to drive the differentiation of B cells with a regulatory phenotype in vitro.The authors argue that research on the Breg function is limited by the low number of blood samples and higher numbers of Breg that are required for therapeutic adoptive cell transfer for diseases associated with excessive immune activation.Thus, they used various cocktails to stimulate enriched human CD19+ B cells and tested the Breg ratio, viability, proliferation rates, and the expression of major molecules involved in Breg-mediated immunoregulation such as IL-10 and IL-35, as well as in vitro suppressive activity.This helps us better understand the differentiation of Bregs.Moreover, this work offers interesting experimental models and might ultimately enable the development of novel Frontiers in Immunology frontiersin.

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