Multipurpose Drug from Rouwolfia serpentina and Nigella sativa: A Herbal Approach to Treat Hypertension and Hyperlipidemia in Experimental Rodent Model
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Le résumé fourni par la source
Introduction: Hypertension refers to the condition where the pressure of blood towards the artery walls is constantly too excessive. Estimated 17.9 million lives each year is taken by this. Its key etiological factors consist of genetic predisposition, unhealthy lifestyle choices, including immoderate salt intake, obesity, lack of physical activity, and chronic situations like kidney disease or hormonal imbalances. Focusing on herbal medications for this will be safer, and affordable alternatives of unwanted risk and negative effects of synthetic medications. Methods and Materials: Six groups of mice were taken. In group 2-5 high fat diet and 3% NaCl was given to induce disease. Group 3,4 and 5 was treated by the ethanolic extract of Nigella sativa, Rouwolfia Serpentina and mixture of Nigella sativa and Rouwolfia Serpentina respectively. Results and Discussion: It has been observed that in all group hypertension condition was restored significantly (p<0.05). In the treatment groups Rouwolfia Serpentina has displayed best efficiency. The mixture of Rouwolfia Serpentina and Nigella sativa showed 2nd most efficiency. On the other hand, Nigella sativa showed comparatively less but statistically significant (p<0.05) efficacy than others. Nigella sativa significantly (p<0.05) restored disturbed lipid profile (Low density lipoprotein, High density lipoprotein and Triglyceride). Conclusion: As The mixture of the two plant extracts gives both anti-hypertensive and anti- hyperlipidemic activity, it has high potential to be used in hypertension management specially when it is exacerbated by hyperlipidemia and this demands for further study.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multipurpose Drug from Rouwolfia serpentina and Nigella sativa: A Herbal Approach to Treat Hypertension and Hyperlipidemia in Experimental Rodent Model
- Date Crossref
- 29/11/2023
- Éditeur
- Sciencedomain International
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Dhaka Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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East West University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Manarat International University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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North South University Department of Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Sir Salimullah Medical College Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Dhaka Medical College and Hospital pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Clinical Pharmacy and Pharmacology pays non établi dans la noticeUniversité ou école supérieure
Department of Biochemistry and Molecular Biology — University of Dhaka, Department of Pharmacy — East West University et Department of Pharmacy — Manarat International University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.