The American Thyroid Association risk stratification and long-term outcomes of differentiated thyroid cancer: a 20-year follow-up of patients in Saudi Arabia
Rattachement africain : sa, bh, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Studies have reported differing factors associated with poor outcomes in patients with differentiated thyroid cancer (DTC). We aimed to describe our 20 years of experience in the management of thyroid cancer (TC) and identify predictors of treatment outcomes. Methods We conducted a retrospective review of medical records of patients with TC seen in the Thyroid Center at King Saud University Medical City (KSUMC) in Riyadh, Saudi Arabia, between the years 2000 and 2020. Demographic and clinical data including pathological characteristics were collected. The American Thyroid Association (ATA) risk stratification was determined for all patients at the postoperative period as well as the response to therapy at the final follow-up visit. Results A total of 674 patients (mean age: 47.21 years) with TC, 571 (84.7%) of which were women, were included. There were 404 (60.0%) patients with ATA low risk, 127 (18.8%) with intermediate risk, and 143 (21.2%) with high-risk histology. Overall, 461 patients (68.4%) had an excellent response to treatment, 65 (9.6%) had an indeterminate response, 83 (12.3%) had a biochemical incomplete response, and 65 (9.6%) had a structural incomplete response. Patients who had an excellent response were mostly ATA low risk (n = 318 of 431, 68.1%), whereas 40 of 65 patients (61.5%) of those with ATA high-risk histology had a structural incomplete response to treatment. There were significantly more women who had an excellent response compared with men. Obesity, lymphovascular invasion, and size of the tumor were significant predictors of worse outcomes to therapy. Conclusion Tumor size, lymphovascular invasion, and obesity are strong predictors of a worse response to therapy among patients with TC. Patients with obesity should be carefully followed up regardless of their risk stratification in light of the recent compelling evidence associating obesity with thyroid cancer and its higher risk of a worse disease outcome. ATA risk stratification is well correlated with patient long-term outcomes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The American Thyroid Association risk stratification and long-term outcomes of differentiated thyroid cancer: a 20-year follow-up of patients in Saudi Arabia
- Date Crossref
- 17/11/2023
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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King Saud Medical City pays non établi dans la noticeÉtablissement de santé
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King Saud University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Salmaniya Medical Complex pays non établi dans la noticeÉtablissement de santé
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King Saud bin Abdulaziz University for Health Sciences Endocrinology and Diabetes Division pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University Diabetes & Metabolism pays non établi dans la noticeUniversité ou école supérieure
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Government Hospitals Salmaniya Medical Complex pays non établi dans la noticeÉtablissement de santé
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College of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Endocrinology and Diabetes Division pays non établi dans la noticeInstitution
King Saud Medical City, Department of Medicine — King Saud University et Salmaniya Medical Complex, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.