Influence of the Phase Composition of Titanium Alloys on Cell Adhesion and Surface Colonization
Rattachement africain : ru, pl, fr, ar. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The pivotal role of metal implants within the host's body following reconstructive surgery hinges primarily on the initial phase of the process: the adhesion of host cells to the implant's surface and the subsequent colonization by these cells. Notably, titanium alloys represent a significant class of materials used for crafting metal implants. This study, however, marks the first investigation into how the phase composition of titanium alloys, encompassing the volume fractions of the α, β, and ω phases, influences cell adhesion to the implant's surface. Moreover, the research delves into the examination of induced hemolysis and cytotoxicity. To manipulate the phase composition of titanium alloys, various parameters were altered, including the chemical composition of titanium alloys with iron and niobium, annealing temperature, and high-pressure torsion parameters. By systematically adjusting these experimental parameters, we were able to discern the distinct impact of phase composition. As a result, the study unveiled that the colonization of the surfaces of the examined Ti-Nb and Ti-Fe alloys by human multipotent mesenchymal stromal cells exhibits an upward trend with the increasing proportion of the ω phase, concurrently accompanied by a decrease in the α and β phases. These findings signify a new avenue for advancing Ti-based alloys for both permanent implants and temporary fixtures, capitalizing on the ability to regulate the volume fractions of the α, β, and ω phases. Furthermore, the promising characteristics of the ω phase suggest the potential emergence of a third generation of biocompatible Ti alloys, the ω-based materials, following the first-generation α-Ti alloys and second-generation β alloys.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Influence of the Phase Composition of Titanium Alloys on Cell Adhesion and Surface Colonization
- Date Crossref
- 11/11/2023
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Osipyan Institute of Solid State Physics RAS pays non établi dans la noticeStructure de recherche
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National University of Science and Technology Department of Casting Technologies and Artistic Processing of Materials pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Health of the Russian Federation pays non établi dans la noticeOrganisme public
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Institute of Metallurgy and Materials Science pays non établi dans la noticeStructure de recherche
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Polish Academy of Sciences pays non établi dans la noticeOrganisme public
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Centre National de la Recherche Scientifique pays non établi dans la noticeOrganisme public
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National University of Comahue Institute for Research in Engineering Sciences and Technologies National Council for Scientific and Technical Research pays non établi dans la noticeUniversité ou école supérieure
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Process and Material Sciences Laboratory pays non établi dans la noticeStructure de recherche
Osipyan Institute of Solid State Physics RAS, Department of Casting Technologies and Artistic Processing of Materials — National University of Science and Technology et Ministry of Health of the Russian Federation, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.