Protocol for a Magnetic Resonance Imaging (MRI) Study of Participants in the Fever Randomized Controlled Trial: Does fever control prevent brain injury in malaria?
Rattachement africain : Malawi, us, Zambie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Despite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial medications rapidly clear peripheral parasitemia and improve survival, but mortality remains high with no associated decline in post-malaria neurologic injury. A randomized controlled trial of aggressive antipyretic therapy with acetaminophen and ibuprofen (Fever RCT) for malarial fevers being conducted in Malawi and Zambia began enrollment in 2019. We propose to use neuroimaging in the context of the RCT to further evaluate neuroprotective effects of aggressive antipyretic therapy. Methods: This observational magnetic resonance imaging (MRI) ancillary study will obtain neuroimaging and neurodevelopmental and behavioral outcomes in children previously enrolled in the Fever RCT at 1- and 12-months post discharge. Analysis will compare the odds of any brain injury between the aggressive antipyretic therapy and usual care groups based upon MRI structural abnormalities. For children unable to undergo imaging without deep sedation, neurodevelopmental and behavioral outcomes will be used to identify brain injury. Discussion: Neuroimaging is a well-established, valid proxy for neurological outcomes after brain injury in pediatric CNS malaria. This MRI ancillary study will add value to the Fever RCT by determining if treatment with aggressive antipyretic therapy is neuroprotective in CNS malaria. It may also help elucidate the underlying mechanism(s) of neuroprotection and expand upon FEVER RCT safety assessments.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Protocol for a Magnetic Resonance Imaging (MRI) Study of Participants in the Fever Randomized Controlled Trial: Does fever control prevent brain injury in malaria?
- Date Crossref
- 10/11/2023
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kamuzu University of Health Sciences Blantyre Malaria Project Blantyre Malaria Project, Malawi (code pays fourni par la source)Université ou école supérieure
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Michigan State University Department of Osteopathic Medical Specialties pays non établi dans la noticeUniversité ou école supérieure
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Boston Children's Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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University Teaching Hospital Lusaka, Zambie (code pays fourni par la source)Établissement de santé
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University of Rochester Department of Imaging Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Zambia Zambie (code pays fourni par la source)Université ou école supérieure
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Chipata Central Hospital Department of Pediatrics and Child Health Chipata Central Hospital, Zambie (pays nommé en fin d’affiliation)Établissement de santé
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Mpingwe Clinic Malawi (pays nommé en fin d’affiliation)Établissement de santé
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Zambia College of Medicine and Surgery Lusaka, Zambie (pays nommé en fin d’affiliation)Université ou école supérieure
Blantyre Malaria Project — Kamuzu University of Health Sciences (Blantyre Malaria Project, Malawi), Department of Osteopathic Medical Specialties — Michigan State University et Department of Neurology — Boston Children's Hospital, avec 6 autres affiliations. Pays d’affiliation : Malawi, Zambie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.