The Use of Phage as Diagnostic Systems

Résumé fourni par la source

Abstract The most common use of bacteriophage in detection methodology is phage typing. When developing panels of phage which will discriminate between isolates of the same species on the basis of lytic spectrum, phage are chosen specifically because of their narrow (and there-fore discriminatory) host range. Since this is the use of phage most commonly encountered, a general impression has been created that phage have a narrow host range. Hence, one of the most commonly voiced criticisms of phage-based detection methods is that the host range of phage - and therefore any test - is limited, but this is far from the truth. When phage are selected for detection of species or of whole genera, those with the widest host range are chosen. A classic example of this is the phage Felix 01, first described as a broad-host-range phage infecting Salmonella enterica by Cherry et al. (8).

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