Ethylene/ethylene oxide and propylene/ propylene oxide: an evaluation of human biomonitoring and cancer risk

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Abstract Inhaled ethylene and propylene are both metabolized by rats to their epoxides ethylene oxide and propylene oxide. On the basis of pharmacokinetic data for metabolically formed ethylene oxide in rats, a first carcinogenic risk estimation for ethylene was published. Data for humans have been calculated from inhalation experiments with rats. Whereas ethylene is produced endogenously in rats and men, propylene and its reactive metabolite are only observed as anthropogenic air pollutants. For the endogenous production of ethylene, two sources are discussed.

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