Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: Although orthostatic hypotension (OH) can be an early feature of autonomic dysfunction in isolated REM sleep behavior disorder (iRBD), no large-scale studies have examined the frequency of OH in iRBD. In this study, we prospectively evaluated the frequency of OH in a large multicenter iRBD cohort. METHODS: Participants 18 years or older with video polysomnogram-confirmed iRBD were enrolled through the North American Prodromal Synucleinopathy consortium. All participants underwent 3-minute orthostatic stand testing to assess the frequency of OH, and a Δ heart rate/Δ systolic blood pressure (ΔHR/ΔSBP) ratio <0.5 was used to define reduced HR augmentation, suggestive of neurogenic OH. All participants completed a battery of assessments, including the Scales for Outcomes in Parkinson Disease-Autonomic Dysfunction (SCOPA-AUT) and others assessing cognitive, motor, psychiatric, and sensory domains. RESULTS: Of 340 iRBD participants (65 ± 10 years, 82% male), 93 (27%) met criteria for OH (ΔHR/ΔSBP 0.37 ± 0.28; range 0.0-1.57), and of these, 72 (77%) met criteria for OH with reduced HR augmentation (ΔHR/ΔSBP 0.28 ± 0.21; range 0.0-0.5). Supine hypertension (sHTN) was present in 72% of those with OH. Compared with iRBD participants without OH, those with OH were older, reported older age of RBD symptom onset, and had worse olfaction. There was no difference in autonomic symptom scores as measured by SCOPA-AUT. DISCUSSION: OH and sHTN are common in iRBD. However, as patients may have reduced autonomic symptom awareness, orthostatic stand testing should be considered in clinical evaluations. Longitudinal studies are needed to clarify the relationship between OH and phenoconversion risk in iRBD. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov: NCT03623672; North American Prodromal Synucleinopathy Consortium.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder
- Date Crossref
- 12/12/2023
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
VA Portland Health Care System pays non établi dans la noticeÉtablissement de santé
-
Oregon Health & Science University Department of Neurology (J.E.E. pays non établi dans la noticeUniversité ou école supérieure
-
Stanford University Department of Neurology & Neurological Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Massachusetts General Hospital Division of Sleep Medicine pays non établi dans la noticeÉtablissement de santé
-
Banner Sun Health Research Institute pays non établi dans la noticeOrganisation à but non lucratif
-
Stanford Medicine pays non établi dans la noticeÉtablissement de santé
-
Research Service pays non établi dans la noticeInstitution
-
National Center for Rehabilitative Auditory Research pays non établi dans la noticeInstitution
-
Neurology pays non établi dans la noticeInstitution
VA Portland Health Care System, Department of Neurology (J.E.E. — Oregon Health & Science University et Department of Neurology & Neurological Sciences — Stanford University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.