S412 Association Between NAFLD/NASH and Colorectal Polyps and Neoplasms in Young Adults With Obesity: A Retrospective Study

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Introduction: Obesity, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) has been associated with an increased risk of colon polyps and colorectal cancer (CRC). However, whether these patients need to be screened earlier is not well established. Therefore, we aimed to investigate the association between NAFLD/NASH and the presence of colon polyps and CRC in the young obese population. Methods: We conducted a retrospective study using ICD-10 codes from a large cohort of 18- to 45-year-old individuals with obesity (n=626,724) from the Nationwide Inpatient Sample (NIS) database during the years 2016-2018. Participants with a family history of CRC, inflammatory bowel disease, cystic fibrosis, or genetic susceptibility were excluded. Multivariate logistic regression was used to analyze the association between NAFLD/NASH and the presence of polyps, benign and malignant neoplasms in the colon, adjusting for age, gender, morbid obesity, HTN, nicotine dependence, obstructive sleep apnea, hyperlipidemia, and diabetes. Results: After excluding 7,422 participants with the above exclusion criteria, the final dataset included 619,302 individuals. In the multivariate analysis, NAFLD was significantly associated with an increased risk of polyps and benign neoplasms in the colon (OR 3.18, 2.62, respectively; P< 0.001), but not malignant neoplasms (OR 0.91). Moreover, NASH was associated with a significantly higher risk of polyps and benign neoplasms (OR 4.96, and 3.66 respectively; P< 0.001), again not with malignant neoplasms (OR 0.31). These associations were consistent across all subgroups (Table 1). Conclusion: The study found that young patients with obesity and NAFLD were at an increased risk of developing colon polyps, and the risk further increased for those with NASH. The odds for malignant neoplasms were found to be lower in these two populations, however we believe the increased presence of polyps alone is a risk for the further development of CRC. The underlying mechanisms may involve chronic inflammation, oxidative stress, and insulin resistance which promotes the development of growth factors and polyp occurrence. Furthermore, studies indicate that individuals who have pre-existing NAFLD and obesity may have a worse prognosis when diagnosed with CRC. Hence, it may be good practice to screen young patients with obesity and NAFLD/NASH for colon polyps and cancer before the recommended age of 45. Early detection and intervention can help prevent the progression of these conditions. Table 1. - Association Between NAFLD/NASH and the Presence of Polyps, Benign and Malignant Neoplasms in the Colon Polyps Odds Ratio 95% Confidence Interval P-Value Nonalcoholic fatty liver disease (NAFLD) 3.18 2.17-4.52 < 0.001 Nonalcoholic steatohepatitis (NASH) 4.96 2.24-9.39 < 0.001 Benign neoplasms Nonalcoholic fatty liver disease (NAFLD) 2.62 1.88-3.55 < 0.001 Nonalcoholic steatohepatitis (NASH) 3.66 1.74-6.68 < 0.001 Malignant neoplasms Nonalcoholic fatty liver disease (NAFLD) 0.91 0.57-1.38 0.237 Nonalcoholic steatohepatitis (NASH) 0.31 0.02-1.35 0.681

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