Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review
Rattachement africain : de, Kenya, Éthiopie, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: An improved estimation of the clinical sequelae of SARS-CoV-2 infection is crucial in African countries, where the subject has received little attention despite more than 12 million reported cases and evidence that many more people were infected. We reviewed the evidence on prevalence, associated risk factors for long COVID, and systemic or sociocultural determinants of reporting long COVID. METHODS: We conducted a systematic review, searching PubMed, the Living OVerview of Evidence platform, and grey literature sources for publications from Dec 1, 2019, to Nov 23, 2022. We included articles published in English, French, Spanish, or Portuguese that reported on any study type in Africa with participants of any age who had symptoms for 4 weeks or more after an acute SARS-CoV-2 infection. We excluded secondary research, comments, and correspondence. Screening and data extraction were performed by two reviewers. Summary estimates were extracted, including sociodemographic factors, medical history, prevalence of persistent symptoms, and symptoms and associated factors. Results were analysed descriptively. The study was registered on the Open Science Framework platform. FINDINGS: Our search yielded 294 articles, of which 24 peer-reviewed manuscripts were included, reporting on 9712 patients from eight African countries. Only one study exclusively recruited children, and one other study included children as part of their study population. Studies indicated moderate to low risk of bias. Prevalence of long COVID varied widely, from 2% in Ghana to 86% in Egypt. Long COVID was positively associated with female sex, older age, non-Black ethnicity, low level of education, and the severity of acute infection and underlying comorbidity. HIV and tuberculosis were not identified as risk factors. Factors influencing reporting included absence of awareness, inadequate clinical data and diagnostics, and little access to health-care services. INTERPRETATION: In Africa, research on long COVID is scarce, particularly among children, who represent the majority of the population. However, existing studies show a substantial prevalence across settings, emphasising the importance of vaccination and other prevention strategies to avert the effects of long COVID on individual wellbeing, the increased strain on health systems, and the potential negative effects on economically vulnerable populations. At a global level, including African countries, tools for research on long COVID need to be harmonised to maximise the usefulness of the data collected. FUNDING: None.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review
- Date Crossref
- 01/11/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Robert Koch Institute Centre for International Health Protection pays non établi dans la noticeOrganisme public
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Kenya Medical Research Institute Kenya (code pays fourni par la source)Structure de recherche
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KEMRI-Wellcome Trust Research Programme Nairobi, Kenya (code pays fourni par la source)Structure de recherche
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Berlin Institute of Health at Charité - Universitätsmedizin Berlin pays non établi dans la noticeStructure de recherche
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Charité - Universitätsmedizin Berlin pays non établi dans la noticeÉtablissement de santé
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Africa Centres for Disease Control and Prevention Éthiopie (code pays fourni par la source)Organisation à but non lucratif
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London School of Hygiene & Tropical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Wellcome Trust Nairobi, Kenya (pays nommé en fin d’affiliation)Organisation à but non lucratif
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Institute of General Practice and Family Medicine pays non établi dans la noticeStructure de recherche
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Division of Disease Control and Prevention Addis Ababa, Éthiopie (pays nommé en fin d’affiliation)Institution
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London School of Hygiene and Tropical Medicine Kenya Nairobi, Kenya (pays nommé en fin d’affiliation)Université ou école supérieure
Centre for International Health Protection — Robert Koch Institute, Kenya Medical Research Institute (Kenya) et KEMRI-Wellcome Trust Research Programme (Nairobi, Kenya), avec 8 autres affiliations. Pays d’affiliation : Kenya, Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.