Editorial: Protein-RNA interplay-regulated signaling in stem cells and cancer

Le résumé fourni par la source

Editorial on the Research Topic Protein-RNA interplay-regulated signaling in stem cells and cancerThe RNA-protein interplay has been proven to be essential for precise regulation of both RNA and protein, which has many implications in various biological processes including stem cell maintenance, differentiation, carcinogenesis and so on (Ye and Blelloch, 2014;Pereira et al., 2017).More specifically, RNA binding proteins (RBPs) have been shown to regulate RNA metabolism ranging from transcription, modification, processing, nuclear export, translation to RNA decay (Hentze et al., 2018;He et al., 2023).On the other hand, RNA molecules have also been shown to regulate RBP functions such as protein stability, enzymatic activity, translocations (Ni et al., 2019;Deng et al., 2020;Huppertz et al., 2022).In this Research Topic, we focused mainly on the RNA-protein interplay in specific physiological (e.g., stem cell and neurogenesis) and pathological (e.g., cancer or heart diseases) contexts, with emphasis on the RNA modifications in cancer.Mammalian development begins with a fertilized egg.This process is associated with proper organ or tissue formation with precise cell fate determination.Deng et al. reviewed how RNA degradation machinery selectively clears specific transcripts during early cell fate determinations including maternal-to-zygotic transition, pluripotency maintenance, as well as somatic cell reprogramming Deng et al.Moreover, Chan et al. reviewed the function of many RBPs (e.g., CPEB3, FXR2) in later-stage adult neurogenesis.The authors also discussed that RBPs are involved in many aspects of neurogenesis including cell proliferation, migration, and differentiation (Chan et al., 2022).The dysregulation of RNA-protein interplay leads to diseases including neuronal diseases, learning defects as discussed by Chan and colleagues (Chan et al., 2022).Moreover, its dysfunction can also cause many other diseases including various cancers and heart diseases.In this Research Topic, Xu et al. demonstrated that 13 out of 14 5methylcytosine (m 5 C)-associated RBPs are generally amplified in ovarian cancer, suggesting

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.