Accès ouvert déclaré 2023 article

Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy

Sébastien Kenmoe, Helen Y. Chu, Fatimah S. Dawood, Jennifer Milucky, Wanitchaya Kittikraisak, Hamish Matthewson, Durga Kulkarni, Piyarat Suntarattiwong, Collrane Frivold, Sarita Mohanty, Fiona P. Havers, You Li, Harish Nair, Jeroen Aerssens, Benoît Callendret, Gabriela Ispas, Bahar Ahani, Jessica E. Atwell, Elizabeth M. Begier, Monica F Turiga, Tin Tin Htar, Mathieu Bangert, Rolf Kramer, Charlotte Vernhes, Philippe Beutels, Louis J Bont, Harry J. Campbell, Richard Osei‐Yeboah, Xin Wang, Rachel Cohen, Gaël Dos Santos, Philip Joosten, Theo Last, Veena R. Kumar, Núria Machín, Hanna Nohynek, Peter Openshaw, John Paget, Andrew John Pollard, Anne C. Teirlinck, Arantxa Urchueguía-Fornes, Ainara Mira‐Iglesias, Alejandro Orrico‐Sánchez, Javier Díez‐Domingo, Johannesen Caroline Klint, Mark D. Miller, Rafael Mikolajczyk, Terho Heikkinen

22Citations signalées, ce qui n’est pas une note de qualité

8Institutions déclarées

5Pays d’affiliation déclarés

Rattachement africain : gb, us, th, cn, Afrique du Sud. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant individuals the proportion of ARI testing positive for RSV and the RSV incidence rate, RSV-associated hospitalizations, deaths, and perinatal outcomes. METHODS: We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase, Global Health, Web of Science, and Global Index Medicus), and including additional unpublished data. Pregnant individuals with ARI who had respiratory samples tested for RSV were included. We used a random-effects meta-analysis to generate overall proportions and rate estimates across studies. RESULTS: Eleven studies with pregnant individuals recruited between 2010 and 2022 were identified, most of which recruited pregnant individuals in community, inpatient and outpatient settings. Among 8126 pregnant individuals, the proportion with ARI that tested positive for RSV ranged from 0.9% to 10.7%, with a meta-estimate of 3.4% (95% confidence interval [CI], 1.9%-54%). The pooled incidence rate of RSV among pregnant individuals was 26.0 (95% CI, 15.8-36.2) per 1000 person-years. RSV hospitalization rates reported in 2 studies were 2.4 and 3.0 per 1000 person-years. In 5 studies that ascertained RSV-associated deaths among 4708 pregnant individuals, no deaths were reported. Three studies comparing RSV-positive and RSV-negative pregnant individuals found no difference in the odds of miscarriage, stillbirth, low birth weight, and small size for gestational age. RSV-positive pregnant individuals had higher odds of preterm delivery (odds ratio, 3.6 [95% CI, 1.3-10.3]). CONCLUSIONS: Data on RSV-associated hospitalization rates are limited, but available estimates are lower than those reported in older adults and young children. As countries debate whether to include RSV vaccines in maternal vaccination programs, which are primarily intended to protect infants, this information could be useful in shaping vaccine policy decisions.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy
Date Crossref: 12/10/2023
Éditeur: Oxford University Press (OUP)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

University of Edinburgh Usher Institute pays non établi dans la notice
Université ou école supérieure
University of Washington Department of Medicine pays non établi dans la notice
Université ou école supérieure
Centers for Disease Control and Prevention Influenza Program pays non établi dans la notice
Organisme public
National Center for Immunization and Respiratory Diseases pays non établi dans la notice
Structure de recherche
Ministry of Public Health pays non établi dans la notice
Organisme public
Queen Sirikit National Institute of Child Health Pediatric Infectious Diseases Unit pays non établi dans la notice
Établissement de santé
Nanjing Medical University pays non établi dans la notice
Université ou école supérieure
University of the Witwatersrand University of the Witwatersrand, Afrique du Sud (code pays fourni par la source)
Université ou école supérieure
School of Public Health University of the Witwatersrand, Afrique du Sud (pays nommé en fin d’affiliation)
Université ou école supérieure

Usher Institute — University of Edinburgh, Department of Medicine — University of Washington et Influenza Program — Centers for Disease Control and Prevention, avec 6 autres affiliations. Pays d’affiliation : Afrique du Sud.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Respiratory viral infections researchCOVID-19 Impact on ReproductionCOVID-19 Clinical Research Studies

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