Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis
Rattachement africain : fi, ca, tr, nl, gb, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background & Aims: Pathologists quantify liver steatosis as the fraction of lipid droplet-containing hepatocytes out of all hepatocytes, whereas the magnetic resonance-determined proton density fat fraction (PDFF) reflects the tissue triacylglycerol concentration. We investigated the linearity, agreement, and correspondence thresholds between histological steatosis and PDFF across the full clinical spectrum of liver fat content associated with non-alcoholic fatty liver disease. Methods: Using individual patient-level measurements, we conducted a systematic review and meta-analysis of studies comparing histological steatosis with PDFF determined by magnetic resonance spectroscopy or imaging in adults with suspected non-alcoholic fatty liver disease. Linearity was assessed by meta-analysis of correlation coefficients and by linear mixed modelling of pooled data, agreement by Bland-Altman analysis, and thresholds by receiver operating characteristic analysis. To explain observed differences between the methods, we used RNA-seq to determine the fraction of hepatocytes in human liver biopsies. Results: histology. Conclusions: Histological steatosis and PDFF have non-perfect linearity and fundamentally different scales of measurement. Liver fat values obtained using these methods may be rendered comparable by conversion equations or threshold values. Impact and implications: Magnetic resonance-proton density fat fraction (PDFF) is increasingly being used to measure liver fat in place of the invasive liver biopsy. Understanding the relationship between PDFF and histological steatosis fraction is important for preventing misjudgement of clinical status or treatment effects in patient care. Our analysis revealed that histological steatosis fraction is often significantly higher than PDFF, and their association varies across the spectrum of fatty liver severity. These findings are particularly important for physicians and clinical researchers, who may use these data to interpret PDFF measurements in the context of histologically evaluated liver fat content.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis
- Date Crossref
- 01/01/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Helsinki Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Helsinki University Hospital HUS Medical Imaging Center pays non établi dans la noticeÉtablissement de santé
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Minerva Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Institute for Molecular Medicine Finland pays non établi dans la noticeStructure de recherche
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Centre Hospitalier de l’Université de Montréal Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Hacettepe University Liver Imaging Team pays non établi dans la noticeUniversité ou école supérieure
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Amsterdam University Medical Centers pays non établi dans la noticeÉtablissement de santé
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Amsterdam Gastroenterology Endocrinology Metabolism pays non établi dans la noticeÉtablissement de santé
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University of Amsterdam Department of Radiology and Nuclear Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Oxford Radcliffe Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of California San Diego NAFLD Research Center pays non établi dans la noticeUniversité ou école supérieure
Department of Medicine — University of Helsinki, HUS Medical Imaging Center — Helsinki University Hospital et Minerva Foundation, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.