Accès ouvert déclaré
2023
article
Evolution of CD4 T-Cell Count With Age in a Cohort of Young People Growing Up With Perinatally Acquired Human Immunodeficiency Virus
Hannah Castro, Caroline Sabin, Intira Jeannie Collins, Hajra Okhai, Katrine Schou Sandgaard, Caroline Foster, Marthe Le Prevost, Siobhan Crichton, Nigel Klein, Ali Judd, Hermione Lyall, Alasdair Bamford, Karina Butler, Katja Doerholt, Conor Doherty, Julia Kenny, Gillian Letting, Paddy McMaster, Fungai Murau, Edith Nsangi, Andrew Riordan, Fiona Shackley, Delane Shingadia, Sharon Storey, Gareth Tudor‐Williams, Anna Turkova, Steve Welch, Claire Cook, Donna Dobson, Keith Fairbrother, Diana M. Gibb, Helen Peters, Kate Francis, Claire Thorne, Laura Thrasyvoulou, Katy Fidler, Jolanta Bernatoniene, F Manyika, Geoffrey S. Sharpe, Barathi Subramaniam, R A Hague, V Price, J. Norman Flynn, Adílson Lopes Cardoso, M Abou–Rayyah, Kathleen A. Grant, S Yeadon, Stanton Segal, Sarah Hawkins, Maria Dowie, Srini Bandi, Elizabeth Percival, Michael Eisenhut, Karsten Duncan, L Anguvaa, Lynn Wren, Timothy J. Flood, A Pickering, Cynthia Murphy, Julie T. Daniels, Y Lees, Fintan Thompson, AnnaLynn M. Williams, Brian Williams, Susan Pope, S Libeschutz, Lucy Cliffe, S Southall, A Freeman, H P Freeman, Sarah Christie, Alexander Gordon, Laura Jones, Lillian B. Brown, Michael E. Greenberg, Carmela Benson, L Ibberson, Shilpa N. Patel, John Hancock, Katia Prime, Mike Sharland, E. G. Hermione Lyall, Paula Seery, Natalie Kirkhope, Sophie Raghunanan, Dr J Kenny, Ann Callaghan, A Bridgwood, Jonathan Evans, Erin A. Blake, A Yannoulias, Jonathan Ainsworth, Sris Allan, Jane Anderson, Ade Apoola, David Chadwick, Duncan Churchill, Valérie Delpech, David Dunn, Ian Fairley, Rajesh Hembrom, Teresa Hill, Margaret Johnson, Sophie José, Stephen Kegg, Clifford Leen, Dushyant Mital, Adrian Palfreeman, Deenan Pillay, David Price, Frank A. Post, Jillian Pritchard, Anjum Tariq, Roy Trevelion, Janet Lynch, James Hand, Stuart Tilbury, Elaney Youssef, Richard Daly, David Asboe, Sundhiya Mandalia, Sajid Munshi, Ade Adefisan, Chris Taylor, Zachary Gleisner, Fowzia Ibrahim, Lucy J. Campbell, Kirsty Baillie, Ian Williams, Sheila Miller, Chris Wood, Mike Youle, Fiona Lampe, Colette Smith, Rob Tsintas, Clinton Chaloner, Andrew Phillips, Nicky Mackie, Alan Winston, Jonathan Weber, Farhan Ramzan, Mark Carder, Andrew Kerr, David Wilks, Sheila Morris, Sue Allan, Adam Lewszuk, Victoria Ogunbiyi, Sue Mitchell, Christopher H. Hunt, Olanike Okolo, Benjamin Watt, Sarah Russell-Sharpe, Olatunde Fagbayimu, Debra Brain, Liz Radford, Sarah Milgate, Shirley Cumming, Claire Atkinson, Annie Rose, Jeanette Smith, Ilise Gunder, Howard Gees, Gemma Squires, Laura Anderson, Serena Mansfield, L. Tomlinson, Christine LeHegerat, Roberta Box, Tom Hatton, Doreen Herbert, Ian McVittie, Victoria Murtha, Laura Shewan, Zak Connan, Luke M. Gregory, Kathleen Holding, Victoria Chester, Trusha Mistry, Catherine Gatford
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10Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Recent studies have shown a decrease in CD4 count during adolescence in young people with perinatally acquired human immunodeficiency virus (HIV, PHIV). METHODS: Young people with PHIV in the United Kingdom, followed in the Collaborative HIV Paediatric Study who started antiretroviral therapy (ART) from 2000 onward were included. Changes in CD4 count over time from age 10 to 20 years were analyzed using mixed-effects models, and were compared to published CD4 data for the gerneral population. Potential predictors were examined and included demographics, age at ART start, nadir CD4 z score (age-adjusted) in childhood, and time-updated viral load. RESULTS: Of 1258 young people with PHIV included, 669 (53%) were female, median age at ART initiation was 8.3 years, and the median nadir CD4 z score was -4.0. Mean CD4 count was higher in young people with PHIV who started ART before age 10 years and had a nadir CD4 z score ≥-4; these young people with PHIV had a decline in CD4 count after age 10 that was comparable to that of the general population. Mean CD4 count was lower in young people with PHIV who had started ART before age 10 and had a nadir CD4 z score <-4; for this group, the decline in CD4 count after age 10 was steeper over time. CONCLUSIONS: In children, in addition to starting ART at an early age, optimizing ART to maintain a higher CD4 z score during childhood may be important to maximizing immune reconstitution later in life.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Evolution of CD4 T-Cell Count With Age in a Cohort of Young People Growing Up With Perinatally Acquired Human Immunodeficiency Virus
- Date Crossref
- 11/10/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV Research and TreatmentHIV/AIDS Research and InterventionsHIV-related health complications and treatments