Two-Year Incidence and Cumulative Risk and Predictors of Anal High-Grade Squamous Intraepithelial Lesions (Anal Precancer) Among Women With Human Immunodeficiency Virus
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Le résumé fourni par la source
BACKGROUND: Detection and treatment of anal histologic high-grade squamous intraepithelial lesions (hHSIL) prevents anal cancer. However, anal hHSIL incidence among women with human immunodeficiency virus (HIV, WHIV) remains unknown. Performance of anal high-risk human papillomavirus ([hr]HPV), anal cytology (anal-cyt), and both for hHSIL detection longitudinally over 2 years also remains undetermined. METHODS: We determined 2-year incidence and cumulative risk estimates (2-y-CR) of anal hHSIL among WHIV using prevalence and incidence (per 100 person-years [py]) observations stratified by baseline hrHPV and/or anal-cyt results. RESULTS: In total, 229 WHIV with complete baseline data were included in the analysis; 114 women without prevalent anal hHSIL were followed with 2 annual evaluations. Median age was 51, 63% were Black, and 23% were Hispanic. Anal hrHPV or abnormal anal-cyt was associated with an increased risk of incident anal hHSIL at 2 years (18.9/100py [95% confidence interval {CI} 11.4-31.3] and 13.4/100py [95% CI 8.0-22.7], respectively) compared with no detection of anal HPV or negative cytology (2.8/100py [95% CI 1.1-7.4] and 4.2 [95% CI, 1.8-10.2]) The presence of anal hrHPV with abnormal cytology was associated with 2-y-CR of anal hHSIL of 65.6% (95% CI 55.4%-75%); negative hrHPV with negative cytology was associated with 2-y-CR of anal hHSIL of 9.2% (95% CI 7.0-16.0). CONCLUSIONS: Detection of anal hrHPV or abnormal anal cytology are comparable predictors for 2-y-CR of anal hHSIL. The absence of anal hrHPV combined with negative cytology was predictive of a lower (but measurable) risk of developing anal hHSIL. These findings provide important data to inform anal cancer screening guidelines for WHIV.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Two-Year Incidence and Cumulative Risk and Predictors of Anal High-Grade Squamous Intraepithelial Lesions (Anal Precancer) Among Women With Human Immunodeficiency Virus
- Date Crossref
- 08/10/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Boston University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Icahn School of Medicine at Mount Sinai Department of Population Health Science and Policy pays non établi dans la noticeUniversité ou école supérieure
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University of California Anal Neoplasia Clinic pays non établi dans la noticeUniversité ou école supérieure
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Medical University of South Carolina Department of Public Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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MUSC Hollings Cancer Center pays non établi dans la noticeÉtablissement de santé
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University of Arkansas for Medical Sciences Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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The State University of New Jersey Rutgers pays non établi dans la noticeUniversité ou école supérieure
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Cornell University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Jr. Hospital of Cook County John H. Stroger pays non établi dans la noticeÉtablissement de santé
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Wake Forest University Health Sciences Department of Internal Medicine (Infectious Diseases) pays non établi dans la noticeOrganisation à but non lucratif
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Wake Forest University pays non établi dans la noticeUniversité ou école supérieure
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Montefiore Medical Center pays non établi dans la noticeÉtablissement de santé
Department of Obstetrics and Gynecology — Boston University, Department of Population Health Science and Policy — Icahn School of Medicine at Mount Sinai et Anal Neoplasia Clinic — University of California, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.