Vertebral body replacement for treatment of spinal infections. A retrospective single-center study of 100 cases

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sample sizes have systematically analyzed the risk factors for TOLF.In the present study, we retrospectively collected clinical data from 530 inpatients diagnosed with TOLF, summarized their demographic characteristics, and focused on the relationship between body mass index (BMI) and TOLF.The purpose of this study is to identify independent risk factors for TOLF, specifically the association between BMI and TOLF.Materials and Methods: A total of 856 individuals consisting of 326 controls without ossification of spinal ligaments and 530 TOLF inpatients who underwent thoracic spine decompression surgery at our hospital between January 2013 and September 2020 were included.All subjects were classified into 4 grades: Grade 0) control; Grade 1) single-segment TOLF; Grade 2) multi-segment TOLF; Grade 3) TOLF combined thoracic ossification of the posterior longitudinal ligament (T-OPLL).Logistic regression analysis was performed to identify the risk factors for TOLF.The TOLF index was calculated to assess the severity of TOLF and its relationship with BMI was investigated by correlation analysis.Results: Overall, TOLF patients are most numerous in the 50-59 age group.Age and gender were considered as independent risk factors for Grade 1 and 2. BMI was identified as an independent risk factor for TOLF.Furthermore, BMI was significantly higher in Grade 1 (26.1 VS 24.5 kg/m2, P ¼ 0.0001), Grade 2 (28.2 VS 24.5 kg/m2, P < 0.0001), and Grade 3 (29.1 VS 24.5 kg/m2, P < 0.0001) than Grade 0. Notably, in TOLF patients without combined T-OPLL, BMI was positively correlated with TOLF index; while BMI was negatively correlated with age in younger individuals.Conclusion: BMI is a crucial risk factor for TOLF.It highlights the necessity of close follow-up of asymptomatic TOLF patients with high BMI to detect and treat their TOLF progression promptly.

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