The carbohydrate-deficient transferrin as a marker of chronic alcohol consumption and assessment of its usefulness in patients with cardiovascular diseases – a pilot study
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Le résumé fourni par la source
Abstract Introduction Cardiovascular diseases (CVDs) are the leading cause of death in the world. The dose of 60 g of alcohol / day has been estimated to significantly increase the risk of developing high blood pressure, arrhythmias, hemorrhagic stroke, and cardiomyopathy. The aim of the study was to evaluate the diagnostic value of CDT when compared with gammaglutamyltransferase (GGT), alkaline phosphatase (ALP), N-terminal fragment brain natriuretic peptide (NT pro-BNP) and troponin T biomarkers in patients with heart failure. Materials and Methods The study was conducted on 59 patients with advanced heart failure with reduced ejection fraction (EF<40%). CDT serum levels were measured using CDT kit, Chromsystems Instruments & Chemicals GmbH, Germany and were expressed as a percentage of total transferrin using high-performance liquid chromatography (HPLC). Results Nineteen patients (n = 19) expressed a normal level of carbohydrate deficiency transferrin <1.2% of the total transferrin found in plasma. The results are obtained from 34 patients (n = 34) were within the range doubtful for the test (1.2–2.5%). In 6 Patients (n = 6) the results of more than 2.5% of CDT content were observed, which could indicate chronic alcohol consumption. Conclusions No statistically significant correlations between CDT and troponin T or NT pro-BNP were identified.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The carbohydrate-deficient transferrin as a marker of chronic alcohol consumption and assessment of its usefulness in patients with cardiovascular diseases – a pilot study
- Date Crossref
- 01/01/2023
- Éditeur
- Walter de Gruyter GmbH
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Institute of Cardiology Department of Heart Failure and Transplantation pays non établi dans la noticeStructure de recherche
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Narodowy Instytut Zdrowia Publicznego PZH – Państwowy Instytut Badawczy pays non établi dans la noticeStructure de recherche
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Ludwik Hirszfeld Institute of Immunology and Experimental Therapy pays non établi dans la noticeStructure de recherche
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Gruca Orthopaedic and Trauma Teaching Hospital Department of Rehabilitation pays non établi dans la noticeÉtablissement de santé
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National Institute of Public Health – National Department-Center for Monitoring and Analyses of Population Health Status pays non établi dans la noticeStructure de recherche
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Laboratory of Virology pays non établi dans la noticeStructure de recherche
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Department of Microbiology National Reference Laboratory for Mycobacteria pays non établi dans la noticeStructure de recherche
Department of Heart Failure and Transplantation — Institute of Cardiology, Narodowy Instytut Zdrowia Publicznego PZH – Państwowy Instytut Badawczy et Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.