Accès ouvert déclaré 2023 review

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Ashley Budu‐Aggrey, Anna Kilanowski, Maria Sobczyk, Suyash Shringarpure, Ruth E. Mitchell, Kadri Reis, Anu Reigo, Reedik Mägi, Mari Nelis, Nao Tanaka, Ben Brumpton, Laurent F. Thomas, Pol Solé-Navais, Christopher Flatley, Antonio Espuela‐Ortiz, Esther Herrera‐Luis, Jesus V. T. Lominchar, Jette Bork‐Jensen, Ingo Marenholz, Aleix Arnau‐Soler, Ayoung Jeong, Katherine A. Fawcett, Hansjörg Baurecht, Elke Rodríguez, Alexessander Couto Alves, Ashish Kumar, Patrick Sleiman, Xiao Chang, Carolina Medina‐Gómez, Chen Hu, Cheng‐Jian Xu, Cancan Qi, Sarah El‐Heis, Philip Titcombe, Elie Antoun, João Fadista, Carol A. Wang, Elisabeth Thiering, Baojun Wu, Sara Kress, Dilini M. Kothalawala, Latha Kadalayil, Jiasong Duan, Hongmei Zhang, Sabelo Hadebe, Thomas J. Hoffmann, Eric Jorgenson, Hélène Choquet, Neil Risch, Pål R. Njølstad, Ole A. Andreassen, Stefan Johansson, Catarina Almqvist, Tong Gong, Vilhelmina Ullemar, Robert Karlsson, Patrik K. E. Magnusson, Agnieszka Szwajda, Esteban G. Burchard, Jacob P. Thyssen, Torben Hansen, Line Lund Kårhus, Thomas Meinertz Dantoft, Alexander C.S.N. Jeanrenaud, Ahla Ghauri, Andreas Arnold, Georg Homuth, Susanne Lau, Markus M. Nöthen, Norbert Hübner, Medea Imboden, Alessia Visconti, Mario Falchi, Véronique Bataille, Pirro G. Hysi, Natalia Ballardini, Dorret I. Boomsma, Jouke‐Jan Hottenga, Martina Müller‐Nurasyid, Tarunveer S. Ahluwalia, Jakob Stokholm, Bo Chawes, Ann‐Marie Malby Schoos, Ana Esplugues, Mariona Bustamante, Benjamin A. Raby, Syed Hasan Arshad, Chris German, Tõnu Esko, Lili Milani, Andres Metspalu, Chikashi Terao, Katrina Abuabara, Mari Løset, Kristian Hveem, Bo Jacobsson, Maria Pino‐Yanes, David P. Strachan, Niels Grarup, Allan Linneberg, Young‐Ae Lee, Nicole Probst‐Hensch, Stephan Weidinger, Marjo‐Riitta Järvelin, Erik Melén, Håkon Håkonarson, Alan D. Irvine, Deborah Jarvis, Tamar Nijsten, Liesbeth Duijts, Judith M. Vonk, Gerard H. Koppelmann, Keith M. Godfrey, Sheila J. Barton, Bjarke Feenstra, Craig E. Pennell, Peter D. Sly, Patrick G. Holt, L. Keoki Williams, Hans Bisgaard, Klaus Bønnelykke, John A. Curtin, Angela Simpson, Clare Murray, Tamara Schikowski, Supinda Bunyavanich, Scott T. Weiss, John W. Holloway, Josine L. Min, Sara Brown, Marie Standl, Lavinia Paternoster

140Citations signalées, ce qui n’est pas une note de qualité

101Institutions déclarées

16Pays d’affiliation déclarés

Rattachement africain : gb, de, us, ee, jp, no, se, es, dk, ch, nl, fi, au, Afrique du Sud, is, ie. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Date Crossref: 04/10/2023
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

University of Bristol Medical Research Council Helmholtz Munich Ludwig-Maximilians-Universität München 23andMe (United States)University of Tartu Tokyo Medical and Dental University RIKEN Center for Integrative Medical Sciences The University of Tokyo Norwegian University of Science and Technology St Olav's University Hospital University of Gothenburg Universidad de La Laguna University of Copenhagen Novo Nordisk Foundation Max Delbrück Center Charité - Universitätsmedizin Berlin Swiss Tropical and Public Health Institute University of Basel University of Leicester University of Regensburg University Hospital Schleswig-Holstein University of Lübeck University of Surrey Karolinska Institutet Stockholm South General Hospital Children's Hospital of Philadelphia Rhythm (United states)University of Pennsylvania Erasmus MC University Medical Center Groningen University of Groningen Medizinische Hochschule Hannover Helmholtz Centre for Infection Research Centre for Individualised Infection Medicine Center for Experimental and Clinical Infection Research MRC Lifecourse Epidemiology Unit University of Southampton Statens Serum Institut University of Helsinki Lund University Institute for Molecular Medicine Finland Hunter Medical Research Institute University of Newcastle Australia Henry Ford Health Leibniz Institute of Environmental Medicine University Hospital Southampton NHS Foundation Trust NIHR Southampton Biomedical Research Centre University of Memphis University of Cape Town University of California, San Francisco Regeneron (United States)Kaiser Permanente Haukeland University Hospital University of Bergen Oslo University Hospital University of Oslo Karolinska University Hospital Bispebjerg Hospital Frederiksberg Hospital Center for Clinical Research and Prevention Universitätsmedizin Greifswald University of Bonn University Hospital Bonn King's College London West Hertfordshire Hospitals NHS Trust Amsterdam Public Health Johannes Gutenberg University Mainz University Medical Center of the Johannes Gutenberg University Mainz Steno Diabetes Centers Gentofte Hospital Copenhagen Prospective Studies on Asthma in Childhood Slagelse Hospital Universitat Jaume I Universitat de València Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública Universitat Pompeu Fabra Barcelona Institute for Global Health Brigham and Women's Hospital Harvard University David Hide Asthma and Allergy Research Centre University of Shizuoka Shizuoka General Hospital Norwegian Institute of Public Health Instituto de Salud Carlos III St George's, University of London Imperial College London University of Oulu University of Iceland Trinity College Dublin Public Health England The University of Queensland The Kids Research Institute Australia The University of Western Australia Manchester Academic Health Science Centre Manchester University NHS Foundation Trust Icahn School of Medicine at Mount Sinai Edinburgh Cancer Research German Center for Lung Research Bristol City Council

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Dermatology and Skin DiseasesAsthma and respiratory diseasesIL-33, ST2, and ILC Pathways

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