Investigating into microbiota in the uterine cavity of the unexplained recurrent spontaneous abortion patients in early pregnancy

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Abstract Introduction The majority of unexplained recurrent spontaneous abortion (URSA) cases have been attributed to immune abnormalities. Inappropriate changes in microbiota could lead to immune disorders. However, the specific role of uterine cavity microbiota in URSA remains unclear, and only a limited number of related studies are available for reference. Methods We utilized double-lumen embryo transfer tubes to collect uterine cavity fluid samples from pregnant women in their first trimester. Subsequently, we conducted 16S rRNA sequencing to analyze the composition and abundance of the microbiota in these samples. Results For this study, we enlisted 10 cases of URSA and 28 cases of induced miscarriages during early pregnancy. Microbial communities were detected in all samples of the URSA group (100%, n = 10), whereas none were found in the control group (0%, n = 28). Among the identified microbes, Lactobacillus and Curvibacter were the two most dominant species. Conclusions This study revealed that during early pregnancy, Lactobacillus and Curvibacter were the predominant colonizers in the uterine cavity of URSA patients and were associated with URSA. Consequently, alterations in the dominant microbiota may lead to adverse pregnancy outcomes.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.