Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy
Rattachement africain : se, no. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Gastrointestinal stromal tumour (GIST) is the most common intra-abdominal sarcoma. Risk classification systems, commonly the modified National Institutes of Health consensus criteria, identify tumour properties relating to patient outcomes. However, owing to limited long-term evidence, most guidelines recommend up to 10-year follow-up for all risk groups except very low-risk GIST. METHODS: This retrospective multicentre study included patients who had complete resection of primary, non-metastatic GIST from three Scandinavian sarcoma centres: Gothenburg (2004-2020), Stockholm (2000-2019), and Oslo (2000-2017). Medical records were reviewed for clinical details regarding diagnosis, treatment, and follow-up, and recurrence-free and disease-specific survival evaluated. RESULTS: The total cohort consisted of 1213 patients with GIST. High-risk patients and those treated with tyrosine kinase inhibitors were excluded. The remaining 649 patients were included in the present analysis: 118 with very low-, 381 with low-, and 150 with intermediate-risk GISTs. Five-year recurrence-free survival rates were 100, 98.5, and 100 per cent for the intermediate-, low-, and very low-risk groups respectively (P = 0.246). Disease-specific survival rates 10 years after surgery were 100, 98.4, and 100 per cent for the intermediate-, low-, and very low-risk groups respectively (P = 0.262). CONCLUSION: Patients with completely resected non-high-risk GISTs have an excellent long-term outcome, irrespective of risk group. Follow-up programmes to detect disease recurrences in these patients are probably not indicated.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy
- Date Crossref
- 27/09/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sahlgrenska University Hospital Department of Surgery pays non établi dans la noticeÉtablissement de santé
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University of Gothenburg Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Karolinska University Hospital Department of Head pays non établi dans la noticeÉtablissement de santé
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Oslo University Hospital Department of Abdominal and Paediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Karolinska Institutet Department of Molecular Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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University of Oslo Institute of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Varberg Hospital pays non établi dans la noticeÉtablissement de santé
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Halland Hospital Department of Surgery pays non établi dans la noticeÉtablissement de santé
Department of Surgery — Sahlgrenska University Hospital, Department of Surgery — University of Gothenburg et Department of Head — Karolinska University Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.