Biochemical Profile of People with Down syndrome: About 25 Cases

Résumé fourni par la source

Down syndrome or trisomy 21 is a genetic disease resulting from an additional gain of chromosome 21. It predisposes to multiple pathologies including obesity, infections, diabetes, or hypothyroidism, responsible for various biological abnormalities. This work aimed to determine biochemical profile of congolese persons with Down syndrome, living in Brazzaville (Congo). The study was carried out on 25 persons with Down syndrome. They are cared for in four specialized centers for disabled children. The methodology was based on the determination of glycaemia, proteins and lipids by spectrophotometric and electrophoretic methods. Globally, normal values of total cholesterol, triglycerides, and glucose (except for one person who had moderate hyperglycaemia), were observed. We noted an hyperlipidemia associated with low levels of HDL, LDL, albumin, and alpha 1 globulin. In Conclusion: there is a disturbance in biochemical profile in subjects with Down syndrome, which predispose to diabetes, cardiovascular diseases and opportunistic infections.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.