Gastrointestinal Biomarkers and Their Association with Feeding in the First Five Days of Pediatric Critical Illness
Rattachement africain : nl, ca, be. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Predicting the patients' tolerance to enteral nutrition (EN) would help clinicians optimize individual nutritional intake. This study investigated the course of several gastrointestinal (GI) biomarkers and their association with EN advancement (ENA) longitudinally during pediatric intensive care unit (PICU) admission. METHODS: This is a secondary analysis of the Early versus Late Parenteral Nutrition in the Pediatric Intensive Care Unit randomized controlled trial. EN was started early and increased gradually. The cholecystokinin (CCK), leptin, glucagon, intestinal fatty acid-binding protein 2 (I-FABP2), and citrulline plasma concentrations were measured upon PICU admission, day 3 and day 5. ENA was defined as kcal EN provided as % of predicted resting energy expenditure. The course of the biomarkers and ENA was examined in patients with samples on all time points using Friedman and Wilcoxon signed-rank tests. The association of ENA with the biomarkers was examined using a 2-part mixed-effects model with data of the complete population, adjusted for possible confounders. RESULTS: For 172 patients, median age 8.6 years (first quartile; third quartile: 4.2; 13.4), samples were available, of which 55 had samples on all time points. The median ENA was 0 (0; 0) on admission, 14.5 (0.0; 43.8) on day 3, and 28.0 (7.6; 94.8) on day 5. During PICU stay, CCK and I-FABP2 concentrations decreased significantly, whereas glucagon concentrations increased significantly, and leptin and citrulline remained stable. None of the biomarkers was longitudinally associated with ENA. CONCLUSIONS: Based on the current evidence, CCK, leptin, glucagon, I-FABP2, and citrulline appear to have no added value in predicting ENA in the first 5 days of pediatric critical illness.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gastrointestinal Biomarkers and Their Association with Feeding in the First Five Days of Pediatric Critical Illness
- Date Crossref
- 20/09/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Erasmus MC - Sophia Children’s Hospital Department of Neonatal and Pediatric Intensive Care pays non établi dans la noticeÉtablissement de santé
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University of Toronto Department of Nutritional Sciences pays non établi dans la noticeUniversité ou école supérieure
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Hospital for Sick Children Division of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Amsterdam University Medical Centers Department of Anesthesiology pays non établi dans la noticeÉtablissement de santé
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Erasmus MC pays non établi dans la noticeÉtablissement de santé
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Erasmus University Rotterdam pays non établi dans la noticeUniversité ou école supérieure
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KU Leuven pays non établi dans la noticeUniversité ou école supérieure
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Department of Clinical Chemistry pays non établi dans la noticeÉtablissement de santé
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Department of Internal Medicine pays non établi dans la noticeInstitution
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Department of Clinical Genetics pays non établi dans la noticeÉtablissement de santé
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Department of Epidemiology pays non établi dans la noticeInstitution
Department of Neonatal and Pediatric Intensive Care — Erasmus MC - Sophia Children’s Hospital, Department of Nutritional Sciences — University of Toronto et Division of Gastroenterology — Hospital for Sick Children, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.