Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat
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Le résumé fourni par la source
BACKGROUND: The high individual variability in coping with stress is often attributed to genetic background differences, sustained environmental conditions, or a combination of both. However, the neural mechanisms underlying coping style variability are still poorly understood. METHODS: Here we examined the impact of a single extended emotional challenge on coping style variability and the associated involvement of the hippocampus, medial prefrontal cortex (mPFC), and periaqueductal gray (PAG). Male Sprague-Dawley rats (n = 170) were trained in an extended 2-way shuttle avoidance (eTWSA) task for 7 days, and daily avoidance rates were measured. Forced swim test, elevated plus maze, or Morris water maze was tested before or after eTWSA exposure. Excitotoxic lesion of the hippocampal dentate gyrus (DG) was performed by Ibotenic infusion. Transient pharmacological blocking of DG, mPFC, or PAG was performed by muscimol or CNQX+TTX infusion. RESULTS: Exposing rats to eTWSA was found to lead to naturally developing dichotomous, not continuous, coping styles, which we termed active avoidance (AA) or reactive escape (RE). Prior emotional responses did not predict the developing coping style. AA was associated with beneficial outcomes, including reduced behavioral despair and improved spatial learning. RE led to impaired spatial retrieval. AA was abolished by lesioning or pharmacological blocking of the DG. RE was prevented by blocking mPFC or PAG. CONCLUSION: The results indicate that a single exposure to a significant emotional challenge can lead, in otherwise healthy individuals, to dichotomous development of an active or reactive coping style with distinctive neural correlates and subsequent behavioral significance.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat
- Date Crossref
- 19/09/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Anhui Medical University pays non établi dans la noticeUniversité ou école supérieure
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IBM Research - Haifa pays non établi dans la noticeStructure de recherche
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University of Haifa Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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Kunming Institute of Zoology pays non établi dans la noticeStructure de recherche
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Chinese Academy of Sciences pays non établi dans la noticeOrganisme public
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Central South University Mental Health Institute pays non établi dans la noticeUniversité ou école supérieure
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Soochow University pays non établi dans la noticeUniversité ou école supérieure
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Center for Excellence in Brain Science and Intelligence Technology pays non établi dans la noticeUniversité ou école supérieure
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Second Xiangya Hospital of Central South University pays non établi dans la noticeÉtablissement de santé
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The School of Mental Health and Psychological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Key Laboratory of Animal Models and Human Disease Mechanisms pays non établi dans la noticeStructure de recherche
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CAS Centre for Excellence in Brain Science and Intelligent Technology pays non établi dans la noticeInstitution
Anhui Medical University, IBM Research - Haifa et Department of Psychology — University of Haifa, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.