(Invited) Derivatizing Fullerenes and Metallofullerenes for Biomedicine

Le résumé fourni par la source

Fullerenes and metallofullerenes are excellent building blocks for biomedicines due to their carbon-based structures that allows for biocompatible materials being built with robust C-C covalent bonds. The hexakis-Bingel reaction can introduce up to 12 functional groups onto one C60 core and provide a versatile platform for molecularly precise, “nanoparticle-like” functional materials. In this presentation we hope to report our recent utilization of the hexakisadduct platform in biomedical applications. In the first study we investigated the anti-oxidative behavior of a series of C60 derivatives, where the hexakisadduct turned out to be an excellent reactive oxygen species scavenger. Then we exemplify the ligand introduction to the hexakisadduct core with Gd metallofullerens, which leads to a series of structurally defined, efficient and safe MRI contrast agents.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.