Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
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Le résumé fourni par la source
The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage. The present study aimed to investigate the potential hepatoprotective and nephroprotective effects of Vernonia amygdalina, a medicinal plant with known antioxidant and anti-inflammatory properties, against doxorubicin-induced toxicity in rats. Male Wistar rats were randomly divided into four groups: Control, Doxorubicin (DOX), DOX + Vernonia Amyg-dalina (DOX+VA), and Vernonia amygdalina (VA) alone. DOX and DOX+VA groups were treated with a single intraperitoneal injection of doxorubicin (15 mg/kg body weight). The DOX+VA group received Vernonia amygdalina extract (100, 300, 500 mg/kg body weight) by oral gavage for 14 days following doxorubicin injection. The results demonstrated that Vernonia amygdalina significantly reduced the elevated levels of liver and kidney function biomarkers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, induced by doxorubicin. The histological examination of the liver and kidney tis-sues also confirmed the protective effects of Vernonia amygdalina against doxorubicin-induced damage. Furthermore, Vernonia amygdalina treatment was found to mitigate oxidative stress by restoring the levels of glutathione (GPx), Catalase, NO and SOD and decreasing the level of malondialdehyde (MDA) in liver and kidney tissues. Additionally, Vernonia amygdalina sig-nificantly suppressed the renal injury markers, NGAL, cystatin-c, KIM-1, and NAG. In conclu-sion, the results of this study suggest that Vernonia amygdalina has potent hepatoprotective and nephroprotective effects against doxorubicin-induced toxicity in rats. These protective effects are mediated by its antioxidant, and free radical scavenging properties. Further investigation is needed to determine the potential clinical relevance of Vernonia amygdalina in protecting against the hepatorenal damage induced by doxorubicin in human subjects. Graphical abstract:
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
- Date Crossref
- 19/09/2023
- Éditeur
- Pensoft Publishers
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universitas Sumatera Utara pays non établi dans la noticeUniversité ou école supérieure
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Lincoln University College pays non établi dans la noticeUniversité ou école supérieure
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Biruni University pays non établi dans la noticeUniversité ou école supérieure
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University of Brawijaya pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Mathematics and Natural Sciences Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Animal Science Department of Animal Nutrition pays non établi dans la noticeUniversité ou école supérieure
Universitas Sumatera Utara, Lincoln University College et Biruni University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.