Impact of preoperative red blood cell transfusion on long-term mortality of liver transplantation: A retrospective cohort study
Rattachement africain : kr, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Preoperative red blood cell (RBC) transfusion can induce immune modulation and alloimmunization; however, few studies have investigated the effect of preoperative transfusion and hemoglobin levels that need to be corrected before surgery, especially in critically ill patients such as those with end-stage liver disease who undergo liver transplantation (LT). This study aimed to investigate the effects of preoperative RBC transfusion on long-term mortality in LT recipients. A total of 249 patients who underwent LT at a single center between January 2012 and December 2021 were included in this study. The patients were divided into 2 groups: preoperative transfusion and preoperative non-transfusion. Since the baseline characteristics were significantly different between the 2 groups, we performed propensity score matching, including factors such as the Model for End-Stage Liver Disease score and intraoperative RBC transfusion, to exclude possible biases that could affect prognosis. We analyzed the 5-year mortality rate as the primary outcome. The preoperative transfusion group showed a 4.84-fold higher hazard ratio than that in the preoperative non-transfusion group. There were no differences in 30-day mortality, duration of intensive care unit stay, or graft rejection rate between the 2 groups. Preoperative transfusion could influence long-term mortality in LT, and clinicians should pay attention to RBC transfusion before LT unless the patient is hemodynamically unstable. A large-scale randomized controlled trial is needed to determine the possible mechanisms related to preoperative RBC transfusion, long-term mortality, and the level of anemia that should be corrected before surgery.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of preoperative red blood cell transfusion on long-term mortality of liver transplantation: A retrospective cohort study
- Date Crossref
- 15/09/2023
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Korea University Medical Center pays non établi dans la noticeÉtablissement de santé
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Korea University Department of Anesthesiology and Pain Medicine pays non établi dans la noticeUniversité ou école supérieure
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Changwon National University pays non établi dans la noticeUniversité ou école supérieure
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Changwon Hanmaeum Hospital Department of Anesthesiology and Pain Medicine pays non établi dans la noticeÉtablissement de santé
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102:37(e34914) pays non établi dans la noticeInstitution
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How to cite this article: Seong H pays non établi dans la noticeOrganisation à but non lucratif
Korea University Medical Center, Department of Anesthesiology and Pain Medicine — Korea University et Changwon National University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.