Extracellular vesicles in acute respiratory distress syndrome: Understanding protective and harmful signaling for the development of new therapeutics.
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more thorough understanding of the variegated and cell-specific functions of EVs may lead to the development of safe and effective therapeutics. In this review, we have collected evidence of EVs role in ARDS, revise the main mechanisms of production and internalization and summarize the current therapeutical approaches that have shown the ability to modulate EV signaling.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
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Où se fait cette recherche
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Eastern Virginia Medical School pays non établi dans la noticeUniversité ou école supérieure
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Old Dominion University Frank Reidy Research Center for Bioelectrics pays non établi dans la noticeUniversité ou école supérieure
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Department of Physiological Sciences pays non établi dans la noticeInstitution
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Division of Pulmonary and Critical Care pays non établi dans la noticeInstitution
Eastern Virginia Medical School, Frank Reidy Research Center for Bioelectrics — Old Dominion University et Department of Physiological Sciences, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.