Estimating foraging behavior in rodents using a modified paradigm measuring threat imminence dynamics

Le résumé fourni par la source

Summary Animals display defensive behaviors in response to threats to avoid danger and approach rewards. In nature, these responses did not evolve alone but are always accompanied by motivational conflict. A semi-naturalistic threat imminence continuum model models the approach-avoidance conflict and is able to integrate multiple defensive behaviors into a single paradigm. However, its comprehensive application is hampered by the lack of a detailed protocol and data about some fundamental factors including sex, age, and motivational level. Here, we modified a previously established paradigm measuring threat imminence continuum dynamics, involving modifications of training and testing protocols, and utilization of commercial materials combined with open science codes, making it more standardized and easier to replicate. We demonstrate that foraging behavior is modulated by age, hunger level, and sex. This paradigm can be used to study defensive behaviors in animals in a more naturalistic manner with relevance to human approach-avoid conflicts and associated psychopathologies. Highlights We provide detailed guidance for setting up a modified paradigm for the threat imminence continuum model with commercial materials and open-source codes. We propose a modified paradigm for the threat imminence continuum model to quantify foraging behaviors. Our method enables comparison between groups as a function of multiple factors including age and food restriction. Graphic Summary

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.