Diagnostic Ability of Radiofrequency Ultrasound in Parkinson's Disease Compared to Conventional Transcranial Sonography and Magnetic Resonance Imaging

Le résumé fourni par la source

Parkinson&s;s disease (PD) is the second most common progressive neurodegenerative disease whose main neuropathological feature is the loss of dopaminergic neurons of the substantia nigra (SN) located in the midbrain and the deposition of α-synuclein in neurons. Despite huge achievements in contemporary neurology and neuroimaging, a definitive diagnostic test for PD is not yet available. Transcranial sonography [TCS] is a relatively new method for assessment of the deep brain structures, including midbrain and SN. TCS modification opens up the possibility to track the brain tissue displacements at the scale of micrometers caused by the endogenous quasi-periodic pulsatility in the intracranial basin. This chapter aims to estimate tissue displacement parameters in midbrain using backscattered ultrasound (US) radiofrequency (RF) signals and to compare the diagnostic ability of RF US-based dynamic features of disease affected tissues with conventional TCS (cTCS) and MRI while differentiating patients with PD from HC.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.