Bone strength is reduced in a neonatal androgenized rat model
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Le résumé fourni par la source
Background: Whether polycystic ovary syndrome (PCOS) affects bone health during a woman's lifespan remains controversial. An androgenized rodent model replicated many metabolic and reproductive features of women with PCOS, and we aimed to use it to investigate the impact of androgens on microarchitecture (by micro-CT), bone mechanical strength, bone formation and resorption markers in rats with intact ovaries (SHAM) who underwent oophorectomy. Methods: were employed for the experiments in this study. The protocol of androgenization consisted of the application of 1.25 mg s.c. testosterone propionate beteween days 2-5 of life, while the controls received the same amount of corn oil s.c. as previously established. Androgenized SHAM rats exhibited chronic anovulation identified by vaginal cytology and a reduction in the proportion of corpus luteum in the ovary in comparison to control SHAM rats. The realization of the ovariectomy or SHAM procedure occurred on Day 100 of life. All groups (n = 8) were followed-up for 180 days to address the study endpoints. Results: Micro-CT from androgenized female rats (SHAM) showed a divergence between the trabecular and cortical bone profiles. Compared to SHAM controls, these rats had an increase in trabecular bone mass with a diminution in bone resorption C-terminal telopeptide of type 1 collagen (CTX) (p < 0.05), a concomitant decrease in cortical area and thickness in the femur, and a reduction in the strength of the femur on the mechanical test (p < 0.01). Conclusions: Our results suggest that a reduction in the cortical thickness and cortical area observed in PCOS model rats was associated with a reduced strength of the femur, despite increased trabecular formation. Ovariectomy in the androgenized OVX group limited the progression rate of cortical bone loss, resulting in bone resistance and cortical thickness comparable to those observed in the control OVX group.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Bone strength is reduced in a neonatal androgenized rat model
- Date Crossref
- 01/12/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidad Cooperativa de Colombia pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de Santa Maria pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de Minas Gerais pays non établi dans la noticeUniversité ou école supérieure
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Universidade de São Paulo pays non établi dans la noticeUniversité ou école supérieure
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Cooperative University of Colombia (UCC) Animal Science Department pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Santa Maria (UFSM) Laboratory of Biotechnology and Animal Reproduction - BioRep pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Dentistry Department of Oral Pathology and Surgery pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Engineering Department of Metallurgical and Materials Engineering pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Biomechanics pays non établi dans la noticeUniversité ou école supérieure
Universidad Cooperativa de Colombia, Universidade Federal de Santa Maria et Universidade Federal de Minas Gerais, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.