Proceedings of the 14 th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal

Le résumé fourni par la source

The early brain damage of the premature has been correlated to several risk factors and among them the histological chorioamnionitis (HC).However, the study of the placenta is not systematically performed in the underdeveloped countries.Our study is estimating the frequency of early brain lesions of premature infants and evaluating the attributed risk of HC among the others independent factors. MATERIALS AND METHODS:This case control study was realized at the neonatal service of CHU Mustapha of Algiers from 01/12/2007 to 31/12/2012.801 in born babies were included, aged between 24 to 36 GA +6 days.All the patients benefi ted a histological placental study and cranial ultrasonography (US) within the 72 hours of birth followed by weekly controls until the patients reached the term.The MRI was realized at the acquired term for babies born before 32 weeks or if the US lesions persisted after the acquired term or if the neurological exam remained abnormal.An EEG was systematically realized during the fi rst week of life.24 brain risk factors were studied, among them, histological chorioamnionitis.The statistical method consisted in bi-varied analysis, logistic regression.P inferior to 0.05 was considered signifi cant. RESULTS:The frequency of the brain lesions was 27.3%.The lesions included peri-intraventricular hemorrhages, cystic and non-cystic leukomalacia and the sequelae (post hemorrhagic hydrocephalus, hypotrophy or atrophy of corpus callosum, and cortical atrophy).The global frequency of HC was 14% .Bi-varied analysis revealed 24 perinatal risk factors signifi cantly associated with the brain lesions and among them, HC with an OR=1,95 IC95=1,25-3,04 p=0,001.After adjustment by logistic regression ,8 factors were independent and the HC was an important prognosis factor as it multiplied the risk of the lesions by about 2 with an OR= 1,92 IC95 (1,09-3,37) P=0,024.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.