Temporal Changes in Coronary18F-Fluoride Plaque Uptake in Patients with Coronary Atherosclerosis
Rattachement africain : gb, nz, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Coronary 18F-sodium fluoride (18F-fluoride) uptake is a marker of both atherosclerotic disease activity and disease progression. It is currently unknown whether there are rapid temporal changes in coronary 18F-fluoride uptake and whether these are more marked in those with clinically unstable coronary artery disease. This study aimed to determine the natural history of coronary 18F-fluoride uptake over 12 mo in patients with either advanced chronic coronary artery disease or a recent myocardial infarction. Methods: Patients with established multivessel coronary artery disease and either chronic disease or a recent acute myocardial infarction underwent coronary 18F-fluoride PET and CT angiography, which was repeated at 3, 6, or 12 mo. Coronary 18F-fluoride uptake was assessed in each vessel by measuring the coronary microcalcification activity (CMA). Coronary calcification was quantified by measuring calcium score, mass, and volume. Results: Fifty-nine patients had chronic coronary artery disease (median age, 68 y; 93% male), and 52 patients had a recent myocardial infarction (median age, 65 y; 83% male). Reflecting the greater burden of coronary artery disease, baseline CMA values were higher in those with chronic coronary artery disease. Coronary 18F-fluoride uptake (CMA > 0) was associated with higher baseline calcium scores (294 Agatston units [AU] [interquartile range, 116–483 AU] vs. 72 AU [interquartile range, 8–222 AU]; P < 0.001) and more rapid progression of coronary calcification scores (39 AU [interquartile range, 10–82 AU] vs. 12 AU [interquartile range, 1–36 AU]; P < 0.001) than was the absence of uptake (CMA = 0). Coronary 18F-fluoride uptake did not markedly alter over the course of 3, 6, or 12 mo in patients with either chronic coronary artery disease or a recent myocardial infarction. Conclusion: Coronary 18F-fluoride uptake is associated with the severity and progression of coronary artery disease but does not undergo a rapid dynamic change in patients with chronic or unstable coronary artery disease. This finding suggests that coronary 18F-fluoride uptake is a temporally stable marker of established and progressive disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Temporal Changes in Coronary<sup>18</sup>F-Fluoride Plaque Uptake in Patients with Coronary Atherosclerosis
- Date Crossref
- 17/08/2023
- Éditeur
- Society of Nuclear Medicine
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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British Heart Foundation pays non établi dans la noticeOrganisation à but non lucratif
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University of Edinburgh British Heart Foundation Centre for Cardiovascular Science pays non établi dans la noticeUniversité ou école supérieure
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New Zealand Brain Research Institute pays non établi dans la noticeStructure de recherche
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University of Otago Christchurch Heart Institute pays non établi dans la noticeUniversité ou école supérieure
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The Queen's Medical Research Institute pays non établi dans la noticeOrganisme public
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Cedars-Sinai Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Leicester Department of Cardiovascular Science pays non établi dans la noticeUniversité ou école supérieure
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National Institute for Health and Care Research pays non établi dans la noticeOrganisme public
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NIHR Leicester Biomedical Research Centre pays non établi dans la noticeStructure de recherche
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Biomedical Imaging Research Institute pays non établi dans la noticeStructure de recherche
British Heart Foundation, British Heart Foundation Centre for Cardiovascular Science — University of Edinburgh et New Zealand Brain Research Institute, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.