Effectiveness of kumquat decoction for the improvement of cough caused by SARS-CoV-2 Omicron variants, a multicentre, prospective observational study
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Kumquat decoction is a traditional Chinese medicine formula and has been widely used to alleviate the coronavirus disease 2019 (COVID-19)-related cough in China. However, the effectiveness and safety of kumquat decoction remain unclear. PURPOSE: To assess the effectiveness and safety of kumquat decoction for COVID-19-related cough. STUDY DESIGN: A multicentre, prospective observational study. METHODS: We enrolled consecutive patients with mild-to-moderate COVID-19 from December 31, 2022, to January 3, 2023, during the Omicron phase in Yangshuo County, China. The primary outcome was the time from study baseline to sustained cough resolution by the last follow-up day on January 31, 2023. The effectiveness was evaluated by Cox proportional hazards models based on propensity score analyses. The secondary outcomes were the resolution of cough and other COVID-19-related symptoms by Days 3, 5, and 7. RESULTS: Of 1434 patients, 671 patients were excluded from the analysis of cough resolution. Among the remaining 763 patients, 481 (63.04%) received kumquat decoction, and 282 (36.96%) received usual care. The median age was 38.0 (interquartile range [IQR] 29.0, 50.0) years, and 55.7% were women. During a median follow-up of 7.000 days, 68.2% of patients in the kumquat group achieved sustained cough resolution (93.77 per 1000 person-days) compared to 39.7% in the usual care group (72.94 per 1000 person-days). The differences in restricted mean survival time (RMST) (kumquat decoction minus usual care group) for cough resolution were -0.742 days (95% CI, -1.235 to -0.250, P = 0.003) on Day 7. In the main analysis using propensity-score matching, the adjusted hazard ratio (HR) for cough resolution (kumquat decoction vs. usual care group) was 1.94 (95% CI, 1.48 to 2.53, P < 0.001). Similar findings were found in multiple sensitivity analyses. In addition, the use of kumquat decoction was associated with the resolution of cough, and a stuffy nose on Days 5 and 7, as well as the resolution of sore throat on Day 7 following medication. CONCLUSION: In this study among patients with COVID-19-related cough, receiving kumquat decoction was associated with an earlier resolution of cough symptoms.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effectiveness of kumquat decoction for the improvement of cough caused by SARS-CoV-2 Omicron variants, a multicentre, prospective observational study
- Date Crossref
- 01/11/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Guangzhou University of Chinese Medicine Department of Emergency pays non établi dans la noticeUniversité ou école supérieure
-
Key Laboratory of Guangdong Province pays non établi dans la noticeStructure de recherche
-
Development Research Center pays non établi dans la noticeOrganisme public
-
Chinese Center For Disease Control and Prevention pays non établi dans la noticeOrganisme public
-
Anyang Hospital of Traditional Chinese Medicine pays non établi dans la noticeÉtablissement de santé
-
The Second Clinical College pays non établi dans la noticeUniversité ou école supérieure
-
Guangdong Provincial Key Laboratory of Research on Emergency in TCM pays non établi dans la noticeStructure de recherche
-
Yangshuo County Centre for Disease Control and Prevention pays non établi dans la noticeInstitution
-
Yangshuo County Hospital of Traditional Chinese Medicine pays non établi dans la noticeÉtablissement de santé
-
Yangshuo County Baisha Township Hospital pays non établi dans la noticeÉtablissement de santé
-
Yangshuo County Fuli Township Hospital pays non établi dans la noticeÉtablissement de santé
-
Yangshuo County Gaotian Township Hospital pays non établi dans la noticeÉtablissement de santé
Department of Emergency — Guangzhou University of Chinese Medicine, Key Laboratory of Guangdong Province et Development Research Center, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.